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Literature summary for 2.7.1.36 extracted from

  • Ferreira, E.R.; Horjales, E.; Bonfim-Melo, A.; Cortez, C.; da Silva, C.V.; De Groote, M.; Sobreira, T.J.; Cruz, M.C.; Lima, F.M.; Cordero, E.M.; Yoshida, N.; da Silveira, J.F.; Mortara, R.A.; Bahia, D.
    Unique behavior of Trypanosoma cruzi mevalonate kinase: A conserved glycosomal enzyme involved in host cell invasion and signaling (2016), Sci. Rep., 6, 24610.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
glycosome
-
Trypanosoma cruzi 20015
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
2 * 34000, SDS-PAGE Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (R)-mevalonate Trypanosoma cruzi
-
ADP + (R)-5-phosphomevalonate
-
?
ATP + (R)-mevalonate Trypanosoma cruzi CL Brener
-
ADP + (R)-5-phosphomevalonate
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi Q4CLD0
-
-
Trypanosoma cruzi CL Brener Q4CLD0
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography and Superdex 200 gel filtration Trypanosoma cruzi

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
72.8
-
at pH 7.2 and 37°C Trypanosoma cruzi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-mevalonate
-
Trypanosoma cruzi ADP + (R)-5-phosphomevalonate
-
?
ATP + (R)-mevalonate
-
Trypanosoma cruzi CL Brener ADP + (R)-5-phosphomevalonate
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 34000, SDS-PAGE Trypanosoma cruzi

Synonyms

Synonyms Comment Organism
MVK
-
Trypanosoma cruzi

General Information

General Information Comment Organism
physiological function thebifunctional enzyme, in addition to playing a classical role in isoprenoid synthesis in lycosomes, it is secreted and modulates host cell signaling required for Trypanosoma cruzi invasion Trypanosoma cruzi