Literature summary for 2.7.1.40 extracted from

Shimada, N.; Shinagawa, T.; Ishii, S.
Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein (2008), Genes Cells, 13, 245-254.

Search for more literature for 2.7.1.40

Application

Application	Comment	Organism
medicine	overexpression of promyelocytic leukemia tumor suppressor protein mutant PML-2KA in the cytoplasm suppresses M2-type pyruvate kinase activity and the accumulation of lactate. PML-2KA suppresses the activity of the high-affinity terameric form of M2-type pyruvate kinase, but not of the low-affinity dimeric form	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	overexpression of promyelocytic leukemia tumor suppressor protein mutant PML-2KA in the cytoplasm suppresses M2-type pyruvate kinase activity and the accumulation of lactate. PML-2KA suppresses the activity of the high-affinity terameric form of M2-type pyruvate kinase, but not of the low-affinity dimeric form	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform M2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
More	M2-type enzyme directly interacts with promyelocytic leukemia tumor suppressor protein	Homo sapiens

Synonyms

Synonyms	Comment	Organism
PKM2	-	Homo sapiens

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Release 2023.1 (January 2023)