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Literature summary for 2.7.1.40 extracted from

  • Spoden, G.A.; Rostek, U.; Lechner, S.; Mitterberger, M.; Mazurek, S.; Zwerschke, W.
    Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply (2009), Exp. Cell Res., 315, 2765-2774.
    View publication on PubMed
Search for more literature for 2.7.1.40

Inhibitors

Inhibitors Comment Organism Structure
peptide aptamer 9
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NIH-3T3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphoenolpyruvate
-
 Mus musculus ATP + pyruvate
-
 ?

Subunits

Subunits Comment Organism
dimer or tetramer PKM2 can switch between a highly active tetrameric and an inactive dimeric form Mus musculus

Synonyms

Synonyms Comment Organism
M2-PK
-
 Mus musculus
PKM2
-
 Mus musculus
pyruvate kinase isoenzyme M2
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ADP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction M2-PK inhibition rescues cells from glucose starvation-induced apoptotic cell death by increasing the metabolic activity Mus musculus
physiological function M2-PK is a metabolic sensor which regulates cell proliferation, cell growth and apoptotic cell death in a glucose supply-dependent manner Mus musculus