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Literature summary for 2.7.1.40 extracted from

  • Gao, X.; Wang, H.; Yang, J.J.; Chen, J.; Jie, J.; Li, L.; Zhang, Y.; Liu, Z.R.
    Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals (2013), J. Biol. Chem., 288, 15971-15979.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
D-fructose 1,6-bisphosphate
-
Homo sapiens

Protein Variants

Protein Variants Comment Organism
Y593F the mutant cannot be phosphorylated Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
x * 60000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pyruvate Homo sapiens
-
ADP + phosphoenolpyruvate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
T-98G cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate
-
Homo sapiens ADP + phosphoenolpyruvate
-
?

Subunits

Subunits Comment Organism
? x * 60000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
PKM2
-
Homo sapiens
pyruvate kinase M2
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the conversion between the pyruvate kinase and protein kinase activities of PKM2 are an important mechanism mediating the effects of growth signals in promoting cell proliferation Homo sapiens