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Literature summary for 2.7.1.40 extracted from

  • He, C.L.; Bian, Y.Y.; Xue, Y.; Liu, Z.X.; Zhou, K.Q.; Yao, C.F.; Lin, Y.; Zou, H.F.; Luo, F.X.; Qu, Y.Y.; Zhao, J.Y.; Ye, M.L.; Zhao, S.M.; Xu, W.
    Pyruvate kinase M2 activates mTORC1 by phosphorylating AKT1S1 (2016), Sci. Rep., 6, 21524.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.40

Protein Variants

Protein Variants Comment Organism
K270M inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + AKT1S1 Homo sapiens the enzyme phosphorylates Ser202 and Ser203 of AKT1S1 ADP + phospho-AKT1S1
-
 ?
ATP + pyruvate Homo sapiens
-
 ADP + phosphoenolpyruvate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + AKT1S1 the enzyme phosphorylates Ser202 and Ser203 of AKT1S1 Homo sapiens ADP + phospho-AKT1S1
-
 ?
ATP + pyruvate
-
 Homo sapiens ADP + phosphoenolpyruvate
-
 ?

Synonyms

Synonyms Comment Organism
PKM2
-
 Homo sapiens
pyruvate kinase M2
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism pyruvate kinase M2 activates mTORC1 by phosphorylating its inhibitor AKT1S1 Homo sapiens