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Literature summary for 2.7.1.78 extracted from

  • Levin, C.J.; Zimmerman, S.B.
    A deoxyribonucleic acid kinase from nuclei of rat liver. Purification and properties (1976), J. Biol. Chem., 251, 1767-1774.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
bovine serum albumin
-
Rattus norvegicus
spermidine little influence Rattus norvegicus
spermine little influence Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
Rattus norvegicus
AgNO3
-
Rattus norvegicus
Cu2+ inhibits in presence of MgCl2 Rattus norvegicus
Deoxyribonucleoside triphosphates
-
Rattus norvegicus
Dextran sulfate strong inhibition Rattus norvegicus
heparin strong inhibition Rattus norvegicus
iodoacetate
-
Rattus norvegicus
p-chloromercuribenzoate
-
Rattus norvegicus
Ribonucleoside triphosphates
-
Rattus norvegicus
sulfate
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
ATP pH 5.5, 37°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Rattus norvegicus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Mg2+, Mn2+, Co2+, Zn2+, Ni2+ or Ca2+ are effective Rattus norvegicus
Co2+ Mg2+, Mn2+, Co2+, Zn2+, Ni2+ or Ca2+ are effective Rattus norvegicus
divalent cations absolutely required Rattus norvegicus
divalent cations Mg2+, Mn2+, Co2+, Zn2+, Ni2+ or Ca2+ are effective, descending order Rattus norvegicus
Mg2+ Mg2+, Mn2+, Co2+, Zn2+, Ni2+ or Ca2+ are effective Rattus norvegicus
Mn2+ Mg2+, Mn2+, Co2+, Zn2+, Ni2+ or Ca2+ are effective Rattus norvegicus
Ni2+ Mg2+, Mn2+, Co2+, Zn2+, Ni2+ or Ca2+ are effective in activation Rattus norvegicus
Zn2+ Mg2+, Mn2+, Co2+, Zn2+, Ni2+ or Ca2+ are effective Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5'-dephospho-DNA Rattus norvegicus
-
ADP + 5'-phospho-DNA
-
?
ATP + 5'-dephospho-DNA Rattus norvegicus
-
ADP + 5'-phospho-DNA
-
r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial, 960fold Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.006
-
partially purified enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5'-dephospho-DNA
-
Rattus norvegicus ADP + 5'-phospho-DNA
-
?
ATP + 5'-dephospho-DNA
-
Rattus norvegicus ADP + 5'-phospho-DNA
-
r
ATP + 5'-dephospho-DNA double stranded DNA Rattus norvegicus ADP + 5'-phospho-DNA UDP, ADP, GDP and CDP support the reverse reaction r
ATP + 5'-dephospho-DNA large DNA fragments released by nuclease treatment Rattus norvegicus ADP + 5'-phospho-DNA UDP, ADP, GDP and CDP support the reverse reaction r
ATP + 5'-dephospho-DNA single stranded DNA Rattus norvegicus ADP + 5'-phospho-DNA UDP, ADP, GDP and CDP support the reverse reaction r
ATP + 5'-dephospho-DNA native and heat denatured DNA Rattus norvegicus ADP + 5'-phospho-DNA UDP, ADP, GDP and CDP support the reverse reaction r
ATP + 5'-dephospho-RNA no activity Rattus norvegicus ADP + 5'-phospho-RNA
-
?
ATP + synthetic oligonucleotide no activity with low molecular weight oligonucleotides Rattus norvegicus ADP + oligonucleotide 5'-phosphate
-
?
ATP + synthetic oligonucleotide oligodeoxynucleotides of chain length above 10-12 residues Rattus norvegicus ADP + oligonucleotide 5'-phosphate
-
?
CTP + 5'-dephospho-DNA UDP, ADP, GDP and CDP support the reverse reaction Rattus norvegicus CDP + 5'-phospho-DNA
-
r
GTP + 5'-dephospho-DNA UDP, ADP, GDP and CDP support the reverse reaction Rattus norvegicus GDP + 5'-phospho-DNA
-
r
UTP + 5'-dephospho-DNA UDP, ADP, GDP and CDP support the reverse reaction Rattus norvegicus UDP + 5'-phospho-DNA
-
r

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
65
-
quick inactivation Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
sharp maximum Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
5 6.5 pH 5: about 50% of activity maximum, pH 6.5: about 35% of activity maximum Rattus norvegicus

pH Stability

pH Stability pH Stability Maximum Comment Organism
5.5
-
37°C, unstable below Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Rattus norvegicus
CDP
-
Rattus norvegicus
CTP
-
Rattus norvegicus
GDP
-
Rattus norvegicus
GTP
-
Rattus norvegicus
UDP
-
Rattus norvegicus
UTP
-
Rattus norvegicus