Literature summary for 2.7.10.1 extracted from

Kazlauskas, A.; Cooper, J.A.
Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins (1989), Cell, 58, 1121-1133.

Search for more literature for 2.7.10.1

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09619	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	two platelet-derived growth factor (PDGF)-dependent autophosphorylation sites in the beta subunit of the human PDGF receptor (PDGF-R). The major site of phosphorylation is Tyr857. Tyr751 is a second in vivo site and the major in vitro site. Autophosphorylation in the kinase insert region triggers the binding of the activated PDGF-R to specific cellular proteins, including a PI kinase whose activity is known to be stimulated by PDGF	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	autophosphorylation	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
beta platelet-derived growth factor receptor	-	Homo sapiens

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Release 2023.1 (January 2023)