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Literature summary for 2.7.10.1 extracted from

  • Randi, A.S.; Sancovich, H.A.; Ferramola de Sancovich, A.M.; Loaiza, A.; Kolliker Frers, R.A.; Spinelli, F.; Kleiman de Pisarev, D.L.
    Effect of in vivo administered hexachlorobenzene on epidermal growth factor receptor levels, protein tyrosine kinase activity, and phosphotyrosine content in rat liver (2003), Biochem. Pharmacol., 65, 1495-1506.
    View publication on PubMed
Search for more literature for 2.7.10.1

Activating Compound

Activating Compound Comment Organism Structure
hexachlorobenzene increases after in vivo administration the total epidermal growth factor receptor content and decreases the plasma membrane epidermal growth factor receptor content compared to untreated rats, higher enzyme activity at low doses, reduced enzyme activity at higher doses of hexachlorobenzene Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
hexachlorobenzene increases after in vivo administration the total epidermal growth factor receptor content and decreases the plasma membrane epidermal growth factor receptor content compared to untreated rats, higher enzyme activity at low doses of 1 mg per kg body weight, reduced enzyme activity at higher doses of 100 mg hexachlorobenzene per kg body weight and above, chronic treatment induces a down-regulation of epidermal growth factor receptor and increases the EGFR-tyrosine kinase activity in the microsomal fraction Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-
plasma membrane
-
 Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Rattus norvegicus
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 female Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
 Rattus norvegicus ADP + a [protein]-L-tyrosine phosphate
-
 ?
ATP + a [protein]-L-tyrosine substrates are membrane and cytosolic proteins Rattus norvegicus ADP + a [protein]-L-tyrosine phosphate
-
 ?
ATP + poly-(Glu-Tyr)
-
 Rattus norvegicus ADP + poly-(Glu-Tyr) phosphate Tyr-phosphate ?

Synonyms

Synonyms Comment Organism
EGFR-tyrosine kinase
-
 Rattus norvegicus
epidermal growth factor receptor
-
 Rattus norvegicus
Protein tyrosine kinase
-
 Rattus norvegicus
PTK
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus