Application | Comment | Organism |
---|---|---|
medicine | human ether-a-go-go-related gene channels are regulated by EGFR kinase and Src-family kinases. EGFR kinase likely works on residue Y611. Regulation of human ether-a-go-go-related gene channels by protein tyrosine kinases likely modifies the channel activity and thus alters electrophysiological properties including action potential duration and cell excitability in human heart and neurons | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AG556 | highly selective EGFR kinase inhibitor, 0.01 mM inhibits human ether-a-go-go-related gene channel current and the effect is significantly countered by the protein tyrosine phosphatase inhibitor orthovanadate (1 mM) | Homo sapiens | |
genistein | broad-spectrum protein tyrosine kinase inhibitor, 0.03 mM inhibits human ether-a-go-go-related gene channel current and the effect is significantly countered by the protein tyrosine phosphatase inhibitor orthovanadate (1 mM) | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
EGFR kinase | - |
Homo sapiens |
epidermal growth factor receptor kinase | - |
Homo sapiens |