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Literature summary for 2.7.10.1 extracted from

  • Koch, S.; Jacobi, A.; Ryser, M.; Ehninger, G.; Thiede, C.
    Abnormal localization and accumulation of FLT3-ITD, a mutant receptor tyrosine kinase involved in leukemogenesis (2008), Cells Tissues Organs, 188, 225-235.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information FLT3 wild-type receptor protein is phosphorylated only upon stimulation with FLT3 ligand Homo sapiens

Application

Application Comment Organism
medicine the constitutively active immature mutant FLT3 receptor protein with an internal tandem duplication is aberrantly accumulating intracellularly in an unidentified compartment of the secretory pathway. From its intracellular location, it may be able to recruit additional or different signaling pathways compared to the predominantly surface-localized wild-type FLT3 receptor protein enabling transformation of the cell Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
wild-type and mutant FLT3 receptor protein expressed in retrovirally transduced COS-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information a mutant FLT3 receptor protein with an internal tandem duplication (FLT3-ITD) accumulates in a perinuclear region and is not detectable at the plasma membrane. Mutant accumulation can neither be detected in the endoplasmic reticulum nor in the Golgi apparatus. The mutant protein resides most probably in an unidentified compartment of the secretory pathway between the endoplasmic reticulum and the Golgi apparatus. FLT3 mutant receptor protein is constitutively phosphorylated and therefore activated. FLT3 wild-type receptor protein expression level is higher than the expression level of the mutant FLT3 receptor protein Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface wild-type FLT3 receptor protein Homo sapiens 9986
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endoplasmic reticulum transient overexpression per se leads to accumulation of wild-type FLT3 receptor protein in the endoplasmic reticulum in addition to surface localization, probably due to inefficient intracellular transport by the overloaded sorting machinery of the secretory pathway Homo sapiens 5783
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
EoL-1 cell wild-type FLT3 receptor protein Homo sapiens
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additional information mutant FLT3 receptor protein present in MV4-11 cells Homo sapiens
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Synonyms

Synonyms Comment Organism
FLT3
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Homo sapiens
FLT3 receptor protein
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Homo sapiens
fms-like tyrosine kinase 3
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Homo sapiens
subclass III receptor tyrosine kinase
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Homo sapiens