Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | FLT3 wild-type receptor protein is phosphorylated only upon stimulation with FLT3 ligand | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | the constitutively active immature mutant FLT3 receptor protein with an internal tandem duplication is aberrantly accumulating intracellularly in an unidentified compartment of the secretory pathway. From its intracellular location, it may be able to recruit additional or different signaling pathways compared to the predominantly surface-localized wild-type FLT3 receptor protein enabling transformation of the cell | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
wild-type and mutant FLT3 receptor protein expressed in retrovirally transduced COS-7 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a mutant FLT3 receptor protein with an internal tandem duplication (FLT3-ITD) accumulates in a perinuclear region and is not detectable at the plasma membrane. Mutant accumulation can neither be detected in the endoplasmic reticulum nor in the Golgi apparatus. The mutant protein resides most probably in an unidentified compartment of the secretory pathway between the endoplasmic reticulum and the Golgi apparatus. FLT3 mutant receptor protein is constitutively phosphorylated and therefore activated. FLT3 wild-type receptor protein expression level is higher than the expression level of the mutant FLT3 receptor protein | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | wild-type FLT3 receptor protein | Homo sapiens | 9986 | - |
endoplasmic reticulum | transient overexpression per se leads to accumulation of wild-type FLT3 receptor protein in the endoplasmic reticulum in addition to surface localization, probably due to inefficient intracellular transport by the overloaded sorting machinery of the secretory pathway | Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
EoL-1 cell | wild-type FLT3 receptor protein | Homo sapiens | - |
additional information | mutant FLT3 receptor protein present in MV4-11 cells | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
FLT3 | - |
Homo sapiens |
FLT3 receptor protein | - |
Homo sapiens |
fms-like tyrosine kinase 3 | - |
Homo sapiens |
subclass III receptor tyrosine kinase | - |
Homo sapiens |