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Literature summary for 2.7.10.1 extracted from
- Adult reproductive functions after early postnatal inhibition by imatinib of the two receptor tyrosine kinases, c-kit and PDGFR, in the rat testis (2008), Reprod. Toxicol., 25, 442-446.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | treatment of cancer with certain molecularly targeted drugs may have latent effects on testicular development by inhibiting specific physiological signaling pathways (stem cell factor/c-kit and platelet-derived growth factor signaling pathways), which must be taken into consideration, when new molecularly designed cancer therapies are introduced into treatment strategies for children | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| imatinib | potently inhibits the tyrosine kinase activities of PDGFR and c-kit. Short postnatal imatinib exposure significantly reduces the litter size sired by the treated animals and leads to permanently slightly elevated serum levels of the gonadotropins. Testicular morphology and mRNA levels of ligands and receptors involved in stem cell factor/c-kit and PDGF signaling return to control levels, and the offsprings are born healthy | Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| testis | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| c-kit | - |
Rattus norvegicus |
| PDGFR | - |
Rattus norvegicus |
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