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Literature summary for 2.7.10.1 extracted from

  • Kim, W.; Prudkin, L.; Feng, L.; Kim, E.; Hennessy, B.; Lee, J.; Lee, J.; Glisson, B.; Lippman, S.; Wistuba, I.; Hong, W.; Lee, H.
    Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors (2012), Cancer, 118, 3993-4003.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine phosphorylated insulinlike growth factor 1 receptor/insulin receptor expression in nonsmall cell lung cancer specimens is associated with a history of tobacco smoking, squamous cell carcinoma histology, mutant K-Ras, and wild-type EGFR, all of which have been strongly associated with poor response to EGFR tyrosine kinase inhibitors. Insulinlike growth factor 1 receptor tyrosine kinase inhibitors exhibit significant antitumor activity in nonsmall cell lung cancer cells with wild-type EGFR and wild-type K-Ras but not in those with mutations in these genes. Introduction of mutant K-Ras attenuates the effects of insulinlike growth factor 1 receptor tyrosine kinase inhibitors on nonsmall cell lung cancer cells expressing wild-type K-Ras. Conversely, inactivation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase restores sensitivity to IGF-tyrosine kinase inhibitors in cells carrying mutant K-Ras Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P08069 insulin-like growth factor 1 receptor
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Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
IGF-1R
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 Homo sapiens
insulin-like growth factor 1 receptor
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 Homo sapiens