Cloned (Comment) | Organism |
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- |
Homo sapiens |
Crystallization (Comment) | Organism |
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molecular docking of inhibitor N-ethyl-5-[2-[4-(5-(ethylamino)-1,3,4-thiadiazol-2-yl)phenylamino]-phenyl]-1,3,4-thiadiazol-2-amine. The 4-(5-ethylamino-1,3,4-thiadiazol-2-yl)phenyl moiety binds the adenine binding pocket. The thiadiazole ring nitrogen N4 interacts with the backbone NH of residue Met793 via hydrogen bond and the 5-ethylamino NH is engaged in a second hydrogen bond with the side-chain OH of Thr 790. The ethyl group is projecting in this narrow pocket near to the Thr790 side-chain | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
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2-[5-(benzylthio)-1,3,4-oxadiazol-2-yl]-N-[4-[5-(benzylthio)-1,3,4-oxadiazol-2-yl]phenyl]aniline | 49% inhibition at 0.01 mM, antiproliferative activity on human breast cancer cell line MCF-7, IC50 value 0.00073 mM | Homo sapiens | |
4-ethyl-3-[2-[4-(4-ethyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)phenylamino]phenyl]-1H-1,2,4-triazole-5(4H)-thione | 52% inhibition at 0.01 mM, antiproliferative activity on human breast cancer cell line MCF-7, IC50 value 0.00238 mM | Homo sapiens | |
N-ethyl-5-[2-[4-(5-(ethylamino)-1,3,4-thiadiazol-2-yl)phenylamino]-phenyl]-1,3,4-thiadiazol-2-amine | 97.7% inhibition at 0.01 mM, antiproliferative activity on human breast cancer cell line MCF-7, IC50 value 0.00094 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00533 | epidermal growth factor receptor tyrosine kinase | - |
Synonyms | Comment | Organism |
---|---|---|
epidermal growth factor receptor tyrosine kinase | - |
Homo sapiens |