Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-(4-hydroxy-5-[(2E)-3-methyl-5-[(1R,2S)-1,2,3-trimethylcyclohex-3-en-1-yl]pent-2-en-1-yl]-3,6-dioxocyclohexa-1,4-dien-1-yl)glycine | IC50 of more than 0.2 mg/ml for EGFR, IC50 of 0.079 mg/ml for HER3 | Homo sapiens | |
N-(5-[(2E)-5-[(1R)-1,3-dimethyl-2-methylidenecyclohex-3-en-1-yl]-3-methylpent-2-en-1-yl]-4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)-D-serine | IC50 of more than 0.2 mg/ml for EGFR, IC50 of 0.022 mg/ml for HER3 | Homo sapiens | |
N-(5-[(2E)-5-[(1R)-1,3-dimethyl-2-methylidenecyclohex-3-en-1-yl]-3-methylpent-2-en-1-yl]-4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)-D-threonine | IC50 of more than 0.2 mg/ml for EGFR, IC50 of 0.027 mg/ml for HER3 | Homo sapiens | |
N-(5-[(2E)-5-[(1R,3R)-1,3-dimethyl-2-methylidenecyclohexyl]-3-methylpent-2-en-1-yl]-4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)-D-serine | IC50 of more than 0.2 mg/ml for EGFR, IC50 of 0.018 mg/ml for HER3 | Homo sapiens | |
N-(5-[(2E)-5-[(1R,3R)-1,3-dimethyl-2-methylidenecyclohexyl]-3-methylpent-2-en-1-yl]-4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)-D-threonine | IC50 of more than 0.2 mg/ml for EGFR, IC50 of 0.19 mg/ml for HER3 | Homo sapiens | |
N-(5-[(2E)-5-[(1R,3R)-1,3-dimethyl-2-methylidenecyclohexyl]-3-methylpent-2-en-1-yl]-4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)glycine | IC50 of 0.197 mg/ml for EGFR, IC50 of 0.125 mg/ml for HER2 | Homo sapiens | |
nakijiquinone C | IC50 of 0.125 mg/ml for EGFR, IC50 of 0.103 mg/ml for HER2 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Egfr | - |
Homo sapiens |
epidermal growth factor receptor | - |
Homo sapiens |
HER2 | - |
Homo sapiens |
human epidermal growth factor receptor2 | - |
Homo sapiens |
RTK | - |
Homo sapiens |