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Literature summary for 2.7.10.1 extracted from

  • Booij, T.; Klop, M.; Yan, K.; Szantai-Kis, C.; Szokol, B.; Orfi, L.; Van De Water, B.; Keri, G.; Price, L.
    Development of a 3D tissue culture-based high-content screening platform that uses phenotypic profiling to discriminate selective inhibitors of receptor tyrosine kinases (2016), J. Biomol. Screen., 21, 912-922.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.10.1

Inhibitors

Inhibitors Comment Organism Structure
afatinib
-
 Homo sapiens
AG1478
-
 Homo sapiens
cabozantinib
-
 Homo sapiens
cetuximab
-
 Homo sapiens
dacomitinib
-
 Homo sapiens
erlotinib
-
 Homo sapiens
foretinib
-
 Homo sapiens
gefitinib
-
 Homo sapiens
Genentech 5D5Fab
-
 Homo sapiens
lapatinib
-
 Homo sapiens
PHA-665752
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell
-
 Homo sapiens
-
prostate adenocarcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?
ATP + poly-Ala-Glu-Lys-Tyr substrate used for c-Met Homo sapiens ADP * poly-Ala-L-Glu-L-Lys-L-tyrosine phosphate
-
 ?
ATP + poly-Glu-Tyr substrate used for EGFR Homo sapiens ADP + poly-L-Glu-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
c-met
-
 Homo sapiens
Egfr
-
 Homo sapiens