Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | Syk requires 20 mM, Fyn and Abl require 10 mM | Homo sapiens | |
Mn2+ | Syk requires 5 mM, Fyn requires 10 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [c-Cbl]-L-tyrosine | Homo sapiens | proto-oncogenic PTK protein substrate | ADP + [c-Cbl]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [c-Cbl]-L-tyrosine | proto-oncogenic PTK protein substrate | Homo sapiens | ADP + [c-Cbl]-L-tyrosine phosphate | - |
? | |
ATP + [c-Cbl]-L-tyrosine | activity and phosphorylation patterns of Syk, Fyn, and Abl with recombinant wild-type and mutant Y700F, Y731F, and Y774F c-Cbl proteins, phosphorylation site preferences are determined by interaction of the enzymes' SH2 domain with the substrate via p85, a phosphatidylinositol 3-kinase, overview | Homo sapiens | ADP + [c-Cbl]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Abl | - |
Homo sapiens |
Fyn | - |
Homo sapiens |
More | Syk, Fyn, and Abl belong to the Src family of PTKs | Homo sapiens |
Protein tyrosine kinase | - |
Homo sapiens |
PTK | - |
Homo sapiens |
Syk | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |