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Literature summary for 2.7.10.2 extracted from
- Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma (2003), Genes Chromosomes Cancer, 37, 427-432.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene ALK is fused to several other genes, NPM, TPM3, TPM4, TFG, ATIC, CLTC, MSN, ALO17, and the non-muscle myosin heavy chain gene MYH9, resulting in expression of chimeric ALK transcripts translated into fusion proteins with tyrosine kinase activity and oncogenic properties, DNA sequence determination and analysis of ALK-MYH9 fusion gene | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | ALK | Homo sapiens | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens |  |
| Mn2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | ALK-MYH9 performs tyrosine autophosphorylation in vivo, but not in vitro, possible mechanism | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
12-year old female | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | ALK-MYH9 is tyrosine phosphorylated in vivo, but not in vitro | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| anaplastic large cell lymphoma cell | specific expression of ALK-MYH9 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | ALK-MYH9 performs tyrosine autophosphorylation in vivo, but not in vitro, possible mechanism | Homo sapiens | ? | - |
? | |
| additional information | low tyrosine autophosphorylation activities of chimeric Alk-NPM and ALK-TPM3 | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | chimeric ALK-MYH9 probably lacks a functional oligomerization domain | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ALK | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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