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Literature summary for 2.7.10.2 extracted from
- Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes (2006), Am. J. Pathol., 168, 1631-1641.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme performs self-activation by autophosphorylation at tyrosine residues | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the Brk kinase is a potential therapeutic target in lymphomas | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| constitutive expression of Brk in a large proportion of cutaneous T-cell lymphomas and other transformed T- and B-cell populations, e.g. Jurkat or JB6 cells. The kinase is expressed in the nuclear localization and activated state, subcellular localization study, overview | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | impact of siRNA-mediated Brk depletion on malignant T cells constitutively expressing the kinase, Brk depletion reproducibly inhibits proliferation of all three malignant T-cell lines | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | nonactivated enzyme form | Homo sapiens | 5737 | - |
| nucleus | activated enzyme form | Homo sapiens | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens |  |
| Mn2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | tyrosine kinases play a fundamental role in cell proliferation, survival, adhesion, and motility and have also been shown to mediate malignant cell transformation, Brk may play a key role in lymphomagenesis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | the enzyme performs autophosphorylation at tyrosine residues | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lymphocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | tyrosine kinases play a fundamental role in cell proliferation, survival, adhesion, and motility and have also been shown to mediate malignant cell transformation, Brk may play a key role in lymphomagenesis | Homo sapiens | ? | - |
? | |
| additional information | the enzyme performs autophosphorylation at tyrosine residues | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Brk | - |
Homo sapiens |
| PTK6/Sik | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.1 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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