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Literature summary for 2.7.10.2 extracted from
- Targeting vascular cell migration as a strategy for blocking angiogenesis: the central role of focal adhesion protein tyrosine kinase family (2007), Curr. Pharm. Des., 13, 2129-2145.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | FAK and PYK2 are activated in response to motogenic and mitogenic factors by phosphorylation and autophosphorylation | Mus musculus | |
| additional information | FAK and PYK2 are activated in response to motogenic and mitogenic factors by phosphorylation and autophosphorylation | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | endothelial cells lacking FAK fail to form bridging complex between integrins and fibrillar chains | Homo sapiens |
| additional information | knockout fak-/- mice show a heavily compromised phenotype with complete absence of the cardiovascular system and early embryonic lethality, enzyme-deficient endothelial cells shows reduced migration, as well as decreased cell proliferation and survival in vivo | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | mainly unphosphorylated or low-phosphorylated FAK and PYK2 | Mus musculus | 5737 | - |
| cytoplasm | mainly unphosphorylated or low-phosphorylated FAK and PYK2 | Homo sapiens | 5737 | - |
| nucleus | phosphorylation-activated FAK and PYK2 | Mus musculus | 5634 | - |
| nucleus | phosphorylation-activated FAK and PYK2 | Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| gelsolin + ATP | Homo sapiens | phosphorylation by PYK2 increases the binding of gelsolin to phosphoatidylinositol lipids and actin polymerization at the fibroblastic cell periphery | phospho-tyrosinyl gelsolin + ADP | - |
? |  |
| additional information | Mus musculus | enzyme-deficient endothelial cells shows reduced migration, as well as decreased cell proliferation and survival in vivo | ? | - |
? | |
| additional information | Homo sapiens | FAK plays a role in the anoikis phenomenon or anchorage-dependent cell survival, and in angiogenesis and formation of new blood vessels, overview, downstream targets of the FAK and PYK2 are MAP kinases implicated in proliferative processes, PYK2 is an essential linker between G-protein coupled receptor and the MAPK cascade, overview | ? | - |
? | |
| p130Cas + ATP | Homo sapiens | phosphorylation of the Crk and Nck adaptor protein by Fak | phospho-tyrosinyl p130Cas + ADP | - |
? | |
| paxillin + ATP | Homo sapiens | phosphorylation at Tyr31 and Tyr118 by Fak plays a role in tumor cell motility inhibition | phospho-tyrosinyl paxillin + ADP | - |
? | |
| Wiskott-Aldrich syndrome protein + ATP | Homo sapiens | i.e. WASP, phosphorylation by Fak | phospho-tyrosinyl Wiskott-Aldrich syndrome protein + ADP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | the enzyme is activated and translocated upon phosphorylation at tyrosines, and also performs autophosphorylation | Mus musculus |
| phosphoprotein | the enzyme is activated upon phosphorylation and translocated from cytoplasm to the nucleus, phosphorylation of FAK at Tyr576 and Tyr577, and of PYK2 at Tyr579 and Tyr580, the enzyme also performs autophosphorylation | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | PYK2 | Homo sapiens | - |
| endothelium | PYK2 | Mus musculus | - |
| endothelium | PYK2 | Homo sapiens | - |
| epithelial cell | - |
Mus musculus | - |
| epithelial cell | - |
Homo sapiens | - |
| fibroblast | PYK2 | Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| osteoblast | PYK2 | Homo sapiens | - |
| osteoclast | PYK2 | Homo sapiens | - |
| umbilical vein endothelium | i.e. HUVEC | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| gelsolin + ATP | phosphorylation by PYK2 increases the binding of gelsolin to phosphoatidylinositol lipids and actin polymerization at the fibroblastic cell periphery | Homo sapiens | phospho-tyrosinyl gelsolin + ADP | - |
? | |
| gelsolin + ATP | phosphorylation by PYK2 | Homo sapiens | phospho-tyrosinyl gelsolin + ADP | - |
? | |
| additional information | enzyme-deficient endothelial cells shows reduced migration, as well as decreased cell proliferation and survival in vivo | Mus musculus | ? | - |
? | |
| additional information | FAK plays a role in the anoikis phenomenon or anchorage-dependent cell survival, and in angiogenesis and formation of new blood vessels, overview, downstream targets of the FAK and PYK2 are MAP kinases implicated in proliferative processes, PYK2 is an essential linker between G-protein coupled receptor and the MAPK cascade, overview | Homo sapiens | ? | - |
? | |
| additional information | Fak binds interaction partners, e.g. paxillin, talin, and p190RhoGEF, at the FAT domain, i.e. the focal adhesion targeting domain, at the C-terminal domain modulaing the Fak activity, overview | Mus musculus | ? | - |
? | |
| additional information | FAk binds interaction partners, e.g. paxillin, talin, and p190RhoGEF, at the FAT domain, i.e. the focal adhesion targeting domain, at the C-terminal domain modulating the Fak activity, overview | Homo sapiens | ? | - |
? | |
| p130Cas + ATP | phosphorylation of the Crk and Nck adaptor protein by Fak | Homo sapiens | phospho-tyrosinyl p130Cas + ADP | - |
? | |
| paxillin + ATP | phosphorylation at Tyr31 and Tyr118 by Fak plays a role in tumor cell motility inhibition | Homo sapiens | phospho-tyrosinyl paxillin + ADP | - |
? | |
| paxillin + ATP | phosphorylation at Tyr31 and Tyr118 by Fak | Homo sapiens | phospho-tyrosinyl paxillin + ADP | - |
? | |
| Wiskott-Aldrich syndrome protein + ATP | i.e. WASP, phosphorylation by Fak | Homo sapiens | phospho-tyrosinyl Wiskott-Aldrich syndrome protein + ADP | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | PTK domain structure, the C-terminal doamin called FRNK, i.e. Fak-related-non-kinase, comprises several docking regions, overview | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FADK1 | - |
Homo sapiens |
| FADK2 | - |
Homo sapiens |
| FAK | - |
Mus musculus |
| FAK | - |
Homo sapiens |
| FAK2 | - |
Homo sapiens |
| focal adhesion protein tyrosine | - |
Mus musculus |
| focal adhesion protein tyrosine | - |
Homo sapiens |
| More | the enzyme belongs to the protein tyrosine kinase family | Homo sapiens |
| proline-rich tyrosine kinase 2 | - |
Homo sapiens |
| protein tyrosine kinase 2 | - |
Homo sapiens |
| PTK | - |
Homo sapiens |
| Pyk2 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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