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Literature summary for 2.7.10.2 extracted from

  • Nakayama, Y.; Kawana, A.; Igarashi, A.; Yamaguchi, N.
    Involvement of the N-terminal unique domain of Chk tyrosine kinase in Chk-induced tyrosine phosphorylation in the nucleus (2006), Exp. Cell Res., 312, 2252-2263.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
transient overexpression of the GFP-tagged wild-type Chk and the N-terminal domain, as well as of the inactivated enzyme mutant, in HeLa cells and COS-1 cells, overexpression of the enzyme leads to increased tyrosine phosphorylation of protein especially from the nuclear matrix, expression and subcellular localization analysis, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus the N-terminal domain of Chk is associated with the nucleus and the nuclear matrix Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme tyrosine phosphorylates a wide range of proteins, especially nuclear matrix proteins ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme tyrosine phosphorylates a wide range of proteins, especially nuclear matrix proteins Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Chk tyrosine kinase
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Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens