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Literature summary for 2.7.10.2 extracted from

  • Frenzel, K.; Wallace, T.A.; McDoom, I.; Xiao, H.D.; Capecchi, M.R.; Bernstein, K.E.; Sayeski, P.P.
    A functional Jak2 tyrosine kinase domain is essential for mouse development (2006), Exp. Cell Res., 312, 2735-2744.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
Jak2, DNA and amino acid sequence determination and analysis, oc-expression of wild-type Jak2 with increasing amounts of mutant W1038G/E1024A or mutant W1038G/E1024R, the latter is more potent in reducing wild-type enzyme actiivty in a dominant-negative way, overview Mus musculus

Protein Variants

Protein Variants Comment Organism
W1038G/E1046A site-directed mutagenesis, an inactive dominant-negative mutant, construction of transgenic mice, heterologous mutants show reduced enzyme activity and an unaltered phenotype, overview Mus musculus
W1038G/E1046R site-directed mutagenesis, an inactive dominant-negative mutant, construction of transgenic mice, heterologous mutants show reduced enzyme activity and an unaltered phenotype, overview Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme is involved in cytokine signaling ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q62120 Jak2
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is activated via phosphorylation at the activation loop, also by autophosphorylation Mus musculus

Reaction

Reaction Comment Organism Reaction ID
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate residue W1038 is essential for catalytic activity Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in cytokine signaling Mus musculus ?
-
?

Subunits

Subunits Comment Organism
More molecular modeling of the active site of wild-type and mutant Jak2, overview Mus musculus

Synonyms

Synonyms Comment Organism
JAK2
-
Mus musculus
Janus kinase 2
-
Mus musculus
More the enzyme belongs to the Janus family of tyrosine kinases Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus