Activating Compound | Comment | Organism | Structure |
---|---|---|---|
EPQYEEIPIYL | a src kinase activating peptide, binds to the SH2 domain of the src-kinase and activates it, activation of endogenous src-PTKs does not inhibit Kv1.3 channels in T lymphocytes, overview | Homo sapiens | |
additional information | activation of Lck by prolonged hypoxia leading to increased phosphorylation of Kv1.3 channels | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
delivery of active Lck into L929 cells and overexpression of GFP-tagged Y505FLck do not decrease recombinant Kv1.3 currents, on the contrary, activation of endogenous src kinases increase wild-type Kv1.3 currents in T lymphocytes, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Y505F | constitutively active Lck mutant, effect on recombinant Kv1.3 current amplitude and O2 sensitivity, overexpressing LckY505F decreased Kv1.3 current from 2.5±0.3 nA to 2.2±0.2 nA, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine | i.e. PP2, abolishes the hypoxia-induced inhibition of Kv1.3 channels in primaryhumanT lymphocytes | Homo sapiens | |
Hg2+ | at PO2 of about 20 mM | Homo sapiens | |
additional information | no inhibition by 4-amino-7-phenylpyrazolo[3,4-d] pyrimidine, i.e. PP3 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the Src protein tyrosine kinase p56Lck plays a critical role in the O2 sensitivity of Kv1.3 channels and in signalling during hypoxia in T lymphocytes, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
J.CaM1.6 cell | - |
Homo sapiens | - |
T-lymphocyte | primary, CD4+ and CD3+ lymphocytes | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the Src protein tyrosine kinase p56Lck plays a critical role in the O2 sensitivity of Kv1.3 channels and in signalling during hypoxia in T lymphocytes, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Lck | - |
Homo sapiens |
p56lck | - |
Homo sapiens |
src protein tyrosine kinase p56Lck | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |