Activating Compound | Comment | Organism | Structure |
---|---|---|---|
angiotensin subtype 1 receptor | AT-1 receptor | Homo sapiens | |
Epidermal growth factor | EGF | Homo sapiens | |
additional information | c-Abl is regulated also by phosphorylation | Homo sapiens | |
platelet-derived growth factor | PDGF | Homo sapiens | |
transforming growth factor beta receptor | TGF-beta receptor | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | the importance of de-regulated c-Abl cytoplasmic signalling in solid tumours is discussed | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
actin cytoskeleton | - |
Homo sapiens | 15629 | - |
cytoplasm | - |
Homo sapiens | 5737 | - |
cytosol | - |
Homo sapiens | 5829 | - |
membrane | - |
Homo sapiens | 16020 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | Homo sapiens | - |
ADP + [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | isoform 1b has a myristoylation site | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | - |
Homo sapiens | ADP + [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
c-Abl tyrosine kinase | isoforms 1a and 1b | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |