Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Lyn kinase | as part of the activation process Lyn phosphorylates Btk in Tyr551, which is subsequently autophosphorylated in Tyr223 | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | X-linked agammaglobulinaemia is a primary immune deficiency characterized by lack of circulating mature B cells, hypogammaglobulinaemia and recurrent infections because of a mutations in the Btk gene | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
for transfection of DT40 lymphoma cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
F540S | mutant, shows absence of Btk phosphorylation on Tyr223 | Homo sapiens |
K374N | mutant, residual kinase activity is present | Homo sapiens |
K430E | mutant, shows absence of Btk phosphorylation on Tyr223 | Homo sapiens |
R288W | mutant, residual kinase activity is present | Homo sapiens |
R28C | mutant | Homo sapiens |
R544G | mutant, residual kinase activity is present | Homo sapiens |
R544S | mutant, residual kinase activity is present | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | Homo sapiens | - |
ADP + [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q06187 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | - |
Homo sapiens | ADP + [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Brutons tyrosine kinase | - |
Homo sapiens |
Btk | - |
Homo sapiens |