Protein Variants | Comment | Organism |
---|---|---|
SW445P | mutation causes constitutive activation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q07912 | ACK1 | - |
Synonyms | Comment | Organism |
---|---|---|
ACK1 | - |
Homo sapiens |
activated Cdc42-associated tyrosine kinase 1 | - |
Homo sapiens |
TNK2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | interaction of the Src homology 3 domain SH3 with the epidermal growth factor receptor-binding domain in isoform ACK1 leads to auto-inhibition of the kinase activity. Release of this auto-inhibition is a key step for activation of ACK1. Mutation of the SH3 domain causes activation of ACK1, independent of cell adhesion. A region at the N-terminus of ACK1, Leu10-Leu14, is essential for cell adhesion-mediated activation. In the activation of ACK1 by epidermal growth factor receptor signalling, growth-factor-receptor-bound protein Grb2 mediates the interaction of ACK1 with epidermal growth factor receptor through binding to the epidermal growth factor receptor-binding domain and activates ACK1 by releasing the auto-inhibition | Homo sapiens |