Literature summary for 2.7.10.2 extracted from

Sancier, F.; Dumont, A.; Sirvent, A.; Paquay de Plater, L.; Edmonds, T.; David, G.; Jan, M.; de Montrion, C.; Coge, F.; Leonce, S.; Burbridge, M.; Bruno, A.; Boutin, J.A.; Lockhart, B.; Roche, S.; Cruzalegui, F.
Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells (2011), PLoS ONE, 6, e17237.

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Application

Application	Comment	Organism
medicine	in HT29 colon carcinoma cells, silencing of tyrosine kinase c-Yes, but not of kinase c-Src, selectively leads to an increase of cell clustering associated with a localisation of beta-catenin at cell membranes and a reduction of expression of beta-catenin target genes. c-Yes silencing induces an increase in apoptosis, inhibition of growth in soft-agar and in mouse xenografts, inhibition of cell migration and loss of the capacity to generate liver metastases in mice. Reintroduction of c-Yes, but not c -Src, restores transforming properties of c-Yes depleted cells. c-Yes kinase activity is required for its role in beta-catenin localisation and growth in soft agar, whereas kinase activity is dispensable for its role in cell migration. c-Yes regulates specific oncogenic signalling pathways important for colon cancer progression that are not shared with c-Src	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P07947	YES1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HT-29 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Yes	-	Homo sapiens
YES1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	in HT29 colon carcinoma cells, silencing of tyrosine kinase c-Yes, but not of kinase c-Src, selectively leads to an increase of cell clustering associated with a localisation of beta-catenin at cell membranes and a reduction of expression of beta-catenin target genes. c-Yes silencing induces an increase in apoptosis, inhibition of growth in soft-agar and in mouse xenografts, inhibition of cell migration and loss of the capacity to generate liver metastases in mice. Reintroduction of c-Yes, but not c -Src, restores transforming properties of c-Yes depleted cells. c-Yes kinase activity is required for its role in beta-catenin localisation and growth in soft agar, whereas kinase activity is dispensable for its role in cell migration. c-Yes regulates specific oncogenic signalling pathways important for colon cancer progression that are not shared with c-Src	Homo sapiens

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Release 2023.1 (January 2023)