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Literature summary for 2.7.10.2 extracted from
- The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells (2013), J. Leukoc. Biol., 94, 865-875.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a [protein]-L-tyrosine | Mus musculus | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P35991 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a [protein]-L-tyrosine | - |
Mus musculus | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Bruton's tyrosine kinase | - |
Mus musculus |
| Btk | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme-deficiency leads to a reduction in mature peripheral B cells. Enzyme-deficient mice fail to respond to immunization with type 2 thymus-independent antigens, and accordingly, peripheral B cells from these animals are unresponsive to B cell receptor crosslinking | Mus musculus |
| physiological function | the enzyme is essential for B cell activation and differentiation | Mus musculus |
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Release 2023.1 (January 2023)
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