Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Insulin | activated endogenous protein kinase B alpha12fold in L6 myotubes, while after transfection into 293 cells PKBalpha is activated 20fold and 50fold in response to insulin and IGF-1 respectively. In both cells, the activation of PKBalpha is accompanied by its phosphorylation at Thr308 and Ser473 | Homo sapiens | |
additional information | PKBalpha becomes phosphorylated and activated in insulin/IGF-1-stimulated cells by an upstream kinase(s) | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P31749 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
protein kinase B alpha | - |
Homo sapiens |
RAC-alpha serine/threonine kinase | - |
Homo sapiens |
RAC/Akt kinase | - |
Homo sapiens |