Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | heterozygous germ line mutations in hCHK2 occur in Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in the TP53 gene. hCHK2 is a tumor suppressor gene conferring predisposition to sarcoma, breast cancer, and brain tumors | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O96017 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | heterozygous germ line mutations in hCHK2 occur in Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in the TP53 gene. hCHK2 is a tumor suppressor gene conferring predisposition to sarcoma, breast cancer, and brain tumors | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
serine/threonine-protein kinase Chk2 | - |
Homo sapiens |