Literature summary for 2.7.11.1 extracted from

Stokoe, D.; Caudwell, B.; Cohen, P.T.; Cohen, P.
The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2 (1993), Biochem. J., 296, 843-849.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P49137	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + Lys-Lys-Phe-Asn-Arg-Thr-Leu-Ser-Val-Ala	-	Homo sapiens	ADP + ?	-	?
ATP + protein	minimum sequence required for efficient phosphorylation is Xaa-Xaa-Hyd-Xaa-Arg-Xaa-Xaa-Ser-Xaa-Xaa, where Hyd is a bulky hydrophobic residue (in decreasing order), Phe, Leu, Val, Ala, MAPKAP kinase-2 can not tolerate a proline residue at position n + 1	Homo sapiens	ADP + phosphoprotein	-	?

Synonyms

Synonyms	Comment	Organism
MAP kinase activated protein kinase 2	-	Homo sapiens
MAPKAP kinase-2	-	Homo sapiens

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Release 2023.1 (January 2023)