Cloned (Comment) | Organism |
---|---|
- |
Xenopus laevis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Xenopus laevis | Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control | ? | - |
? | |
additional information | Xenopus laevis | the damage/replication G2 checkpoint kinase Chk1 phosphorylates and inhibits Cdc25C, a Cdc2 Tyr-15 phosphatase, thereby directly linking the G2 checkpoint to negative regulation of Cdc2. Might function either as a G2 checkpoint kinase or as an ordinary cell cycle regulator in prophase-I-arrested oocytes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Xenopus laevis | Q6DE87 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Xchk1 is highly phosphorylated in the presence of unreplicated or damaged DNA, and this phosphorylation is abolished by caffeine | Xenopus laevis |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Cdc25C | - |
Xenopus laevis | ADP + phosphorylated Cdc25C | - |
? | |
additional information | Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control | Xenopus laevis | ? | - |
? | |
additional information | the damage/replication G2 checkpoint kinase Chk1 phosphorylates and inhibits Cdc25C, a Cdc2 Tyr-15 phosphatase, thereby directly linking the G2 checkpoint to negative regulation of Cdc2. Might function either as a G2 checkpoint kinase or as an ordinary cell cycle regulator in prophase-I-arrested oocytes | Xenopus laevis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Chk1 kinase | - |
Xenopus laevis |
serine/threonine-protein kinase Chk1 | - |
Xenopus laevis |