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Literature summary for 2.7.11.1 extracted from

  • Nakajo, N.; Oe, T.; Uto, K.; Sagata, N.
    Involvement of Chk1 kinase in prophase I arrest of Xenopus oocytes (1999), Dev. Biol., 207, 432-444.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
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Xenopus laevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Xenopus laevis Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control ?
-
?
additional information Xenopus laevis the damage/replication G2 checkpoint kinase Chk1 phosphorylates and inhibits Cdc25C, a Cdc2 Tyr-15 phosphatase, thereby directly linking the G2 checkpoint to negative regulation of Cdc2. Might function either as a G2 checkpoint kinase or as an ordinary cell cycle regulator in prophase-I-arrested oocytes ?
-
?

Organism

Organism UniProt Comment Textmining
Xenopus laevis Q6DE87
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Xchk1 is highly phosphorylated in the presence of unreplicated or damaged DNA, and this phosphorylation is abolished by caffeine Xenopus laevis

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Cdc25C
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Xenopus laevis ADP + phosphorylated Cdc25C
-
?
additional information Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control Xenopus laevis ?
-
?
additional information the damage/replication G2 checkpoint kinase Chk1 phosphorylates and inhibits Cdc25C, a Cdc2 Tyr-15 phosphatase, thereby directly linking the G2 checkpoint to negative regulation of Cdc2. Might function either as a G2 checkpoint kinase or as an ordinary cell cycle regulator in prophase-I-arrested oocytes Xenopus laevis ?
-
?

Synonyms

Synonyms Comment Organism
Chk1 kinase
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Xenopus laevis
serine/threonine-protein kinase Chk1
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Xenopus laevis