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Literature summary for 2.7.11.1 extracted from
- Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes (1995), J. Biol. Chem., 270, 12717-12724.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| heparin | activation with peptide substrate | Rattus norvegicus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed as active enzyme in Escherichia coli | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| heparin | inhibition with casein and phosvitin as substrate | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | autophosphorylation when incubated with ATP and Mg2+ | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
- |
Rattus norvegicus |
| 45500 | - |
- |
Rattus norvegicus |
| 49700 | - |
- |
Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | Q62761 | - |
- |
| Rattus norvegicus | Q62762 | - |
- |
| Rattus norvegicus | Q62763 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Rattus norvegicus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme, partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| muscle | - |
Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | autophosphorylation when incubated with ATP and Mg2+ | Rattus norvegicus | ADP + a phosphoprotein | - |
? | |
| ATP + casein | - |
Rattus norvegicus | ADP + phosphorylated casein | - |
? | |
| ATP + phosvitin | - |
Rattus norvegicus | ADP + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| casein kinase I, gamma 1 isoform | - |
Rattus norvegicus |
| casein kinase I, gamma 2 isoform | - |
Rattus norvegicus |
| casein kinase I, gamma 3 isoform | - |
Rattus norvegicus |
| CK1 gamma 1 | - |
Rattus norvegicus |
| CK1 gamma 2 | - |
Rattus norvegicus |
| CK1 gamma 3 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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