Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | S6K2 is phosphorylated at T228, T338, and S370 leading to activation, T338 plays the key role | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
S370A | site-directed mutagenesis, S6K2 mutant is inactive | Mus musculus |
S370D | site-directed mutagenesis, S6K2 mutant is inactive | Mus musculus |
T228A | site-directed mutagenesis, S6K2 mutant shows reduced activation compared to the wild-type enzyme | Mus musculus |
T228A/T338E | site-directed mutagenesis, S6K2 mutant is inactive | Mus musculus |
T228E | site-directed mutagenesis, S6K2 mutant shows highly reduced activation compared to the wild-type enzyme | Mus musculus |
T338E | site-directed mutagenesis, S6K2 mutant is fully active and rapamycin-resistant, while the S6K1 mutant is inactive | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition of S6K2 by wortmannin or rapamycin, S6K2 phosphorylation by MEK of S410, S417, and S423 of the autoinhibition domain leads to inhibition of the enzyme | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
ribosome | - |
Mus musculus | 5840 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Mus musculus | - |
ADP + a phosphoprotein | - |
? | |
additional information | Mus musculus | mechanism of S6K2 regulation via phosphorylation and autoinhibition with T338 playing the key role, S6K2 is regulated in a mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase MEK-dependent manner, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
p70 ribosomal S6 kinase 1 S6K1 and its homologue ribosomal S6 kinase 2 S6K2 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of S6K2 is regulated via interdependent steps, overview, S6K2 is phosphorylated at T228 by PDK1 and at T338, playing the key role, and at S370, leading to activation, phosphorylation of S410, S417, and S423 of the autoinhibition domain by MEK leads to inhibition of the enzyme | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Mus musculus | ADP + a phosphoprotein | - |
? | |
additional information | mechanism of S6K2 regulation via phosphorylation and autoinhibition with T338 playing the key role, S6K2 is regulated in a mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase MEK-dependent manner, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
p70 ribosomal S6 kinase 1 | - |
Mus musculus |
ribosomal S6 kinase 2 | - |
Mus musculus |
S6K1 | - |
Mus musculus |
S6K2 | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |