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Literature summary for 2.7.11.1 extracted from

  • Phin, S.; Kupferwasser, D.; Lam, J.; Lee-Fruman, K.K.
    Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1 (2003), Biochem. J., 373, 583-591.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information S6K2 is phosphorylated at T228, T338, and S370 leading to activation, T338 plays the key role Mus musculus

Protein Variants

Protein Variants Comment Organism
S370A site-directed mutagenesis, S6K2 mutant is inactive Mus musculus
S370D site-directed mutagenesis, S6K2 mutant is inactive Mus musculus
T228A site-directed mutagenesis, S6K2 mutant shows reduced activation compared to the wild-type enzyme Mus musculus
T228A/T338E site-directed mutagenesis, S6K2 mutant is inactive Mus musculus
T228E site-directed mutagenesis, S6K2 mutant shows highly reduced activation compared to the wild-type enzyme Mus musculus
T338E site-directed mutagenesis, S6K2 mutant is fully active and rapamycin-resistant, while the S6K1 mutant is inactive Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition of S6K2 by wortmannin or rapamycin, S6K2 phosphorylation by MEK of S410, S417, and S423 of the autoinhibition domain leads to inhibition of the enzyme Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
ribosome
-
Mus musculus 5840
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Mus musculus
-
ADP + a phosphoprotein
-
?
additional information Mus musculus mechanism of S6K2 regulation via phosphorylation and autoinhibition with T338 playing the key role, S6K2 is regulated in a mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase MEK-dependent manner, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
p70 ribosomal S6 kinase 1 S6K1 and its homologue ribosomal S6 kinase 2 S6K2
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of S6K2 is regulated via interdependent steps, overview, S6K2 is phosphorylated at T228 by PDK1 and at T338, playing the key role, and at S370, leading to activation, phosphorylation of S410, S417, and S423 of the autoinhibition domain by MEK leads to inhibition of the enzyme Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
Mus musculus ADP + a phosphoprotein
-
?
additional information mechanism of S6K2 regulation via phosphorylation and autoinhibition with T338 playing the key role, S6K2 is regulated in a mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase MEK-dependent manner, overview Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
p70 ribosomal S6 kinase 1
-
Mus musculus
ribosomal S6 kinase 2
-
Mus musculus
S6K1
-
Mus musculus
S6K2
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus