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Literature summary for 2.7.11.1 extracted from
- Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility (2005), Mol. Cell. Biol., 25, 4250-4261.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| SSTK gene, DNA and amino acid sequence determination and analysis, transient expression of Myc-tagged SSTK in 293T cells | Mus musculus |
| SSTK gene, DNA and amino acid sequence determination and analysis, transient expression of wild-type and mutant Myc-tagged SSTK in 293T cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K41M | site-directed mutagenesis, inactive mutant, no interaction with heat shock proteins | Homo sapiens |
| additional information | construction of SSTK knockout mice showing impaired sperm motility and morphology resulting in male sterility, a DNA condensation defect in SSTK null mutants occurred in elongating spermatids at a step in spermiogenesis coincident with chromatin displacement of histones by transition proteins | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | serine/threonine protein kinase is SSTK essential for male fertility | ? | - |
? |  |
| additional information | Mus musculus | serine/threonine protein kinase SSTK is essential for male fertility, a DNA condensation defect in SSTK null mutants occurred in elongating spermatids at a step in spermiogenesis coincident with chromatin displacement of histones by transition proteins | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9BXA6 | - |
- |
| Mus musculus | Q925K9 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | SSTK is ubiquitously expressed in human tissue | Homo sapiens | - |
| spermatid | head of spermatid | Mus musculus | - |
| testis | - |
Mus musculus | - |
| testis | most abundant in | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone H1 | substrate from calf, substrate of SSTK | Homo sapiens | ADP + phosphorylated histone H1 | - |
? | |
| ATP + histone H1 | substrate from calf, substrate of SSTK | Mus musculus | ADP + phosphorylated histone H1 | - |
? | |
| ATP + histone H2A | recombinant human substrate, substrate of SSTK | Homo sapiens | ADP + phosphorylated histone H2A | - |
? | |
| ATP + histone H2A | recombinant human substrate, substrate of SSTK | Mus musculus | ADP + phosphorylated histone H2A | - |
? | |
| ATP + histone H2AX | recombinant human substrate, substrate of SSTK | Homo sapiens | ADP + phosphorylated histone H2AX | - |
? | |
| ATP + histone H2AX | recombinant human substrate, substrate of SSTK | Mus musculus | ADP + phosphorylated histone H2AX | - |
? | |
| ATP + histone H2B | recombinant human substrate, substrate of SSTK | Homo sapiens | ADP + phosphorylated histone H2B | - |
? | |
| ATP + histone H2B | recombinant human substrate, substrate of SSTK | Mus musculus | ADP + phosphorylated histone H2B | - |
? | |
| ATP + histone H4 | recombinant substrate from Xenopus laevis, substrate of SSTK | Homo sapiens | ADP + phosphorylated histone H4 | - |
? | |
| ATP + histone H4 | recombinant substrate from Xenopus laevis, substrate of SSTK | Mus musculus | ADP + phosphorylated histone H4 | - |
? | |
| ATP + myelin basic protein | - |
Homo sapiens | ADP + phosphorylated myelin basic protein | - |
? | |
| ATP + myelin basic protein | - |
Mus musculus | ADP + phosphorylated myelin basic protein | - |
? | |
| additional information | serine/threonine protein kinase is SSTK essential for male fertility | Homo sapiens | ? | - |
? | |
| additional information | serine/threonine protein kinase SSTK is essential for male fertility, a DNA condensation defect in SSTK null mutants occurred in elongating spermatids at a step in spermiogenesis coincident with chromatin displacement of histones by transition proteins | Mus musculus | ? | - |
? | |
| additional information | substrate specificity with diverse peptide substrates, overview, SSTK forms stable complexes with heat shock signal proteins HSP90-1beta, HSC70, and HSP70-1, which seems to be necessary for activity | Mus musculus | ? | - |
? | |
| additional information | substrate specificity with diverse peptide substrates, overview, SSTK forms stable complexes with heat shock signate proteins HSP90-1beta, HSC70, and HSP70-1, which seems to be necessary for activity | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | SSTK is a small enzyme consisting only of the C- and N-terminal lobe of a protein kinase catalytic domain | Homo sapiens |
| More | SSTK is a small enzyme consisting only of the C- and N-terminal lobe of a protein kinase catalytic domain | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| serine/threonine protein kinase | - |
Homo sapiens |
| serine/threonine protein kinase | - |
Mus musculus |
| SSTK | - |
Homo sapiens |
| SSTK | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| ATP | - |
Mus musculus | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | amino acid sequence calculation | - |
9.1 |
| Mus musculus | amino acid sequence calculation | - |
9.1 |
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