Cloned (Comment) | Organism |
---|---|
overexpression of CKI in Drosophila Kc cell line, the sole Drosophila CKIdelta/epsilon gene, but not CKIalpha, activates a wingless transcriptional reporter in the absence of ligand | Drosophila melanogaster |
Protein Variants | Comment | Organism |
---|---|---|
D173N | the dominant-negative form of CKIgamma inhibits Wnt signaling in a reporter assay in 293T cells, and gish RNAi partially blocks transcription induced by Wg in SL2 cells | Drosophila melanogaster |
K73R | the dominant-negative form of CKIgamma inhibits Wnt signaling in a reporter assay in 293T cells, and gish RNAi partially blocks transcription induced by Wg in SL2 cells | Drosophila melanogaster |
additional information | injection of kinase-dead CKIepsilon into early Xenopus embryos causes defects in convergent extension during gastrulation | Xenopus laevis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CKI-7 | - |
Xenopus laevis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + adenomatous polyposis coli protein | Drosophila melanogaster | i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon | ADP + phosphorylated adenomatous polyposis coli protein | - |
? | |
ATP + adenomatous polyposis coli protein | Homo sapiens | i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon | ADP + phosphorylated adenomatous polyposis coli protein | - |
? | |
ATP + adenomatous polyposis coli protein | Xenopus laevis | i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon | ADP + phosphorylated adenomatous polyposis coli protein | - |
? | |
ATP + beta-catenin | Drosophila melanogaster | phosphorylation at Ser45, priming GSK3beta phosphorylation | ADP + phosphorylated beta-catenin | - |
? | |
ATP + beta-catenin | Homo sapiens | phosphorylation at Ser45, priming GSK3beta phosphorylation | ADP + phosphorylated beta-catenin | - |
? | |
ATP + beta-catenin | Xenopus laevis | phosphorylation at Ser45, priming GSK3beta phosphorylation | ADP + phosphorylated beta-catenin | - |
? | |
ATP + Gli protein | Homo sapiens | the Gli proteins are important in regulation of Hedgehog signaling, overview | ADP + phosphorylated Gli protein | - |
? | |
ATP + protein Cubitus interruptus | Drosophila melanogaster | Ci proteins are important in regulation of Hedgehog signaling, overview | ADP + phosphorylated protein Cubitus interruptus | - |
? | |
ATP + protein Cubitus interruptus | Xenopus laevis | Ci proteins are important in regulation of Hedgehog signaling, overview | ADP + phosphorylated protein Cubitus interruptus | - |
? | |
ATP + protein LRP6 | Drosophila melanogaster | CKIgamma | ADP + phosphorylated protein LRP6 | - |
? | |
ATP + protein LRP6 | Homo sapiens | CKIgamma | ADP + phosphorylated protein LRP6 | - |
? | |
ATP + protein LRP6 | Xenopus laevis | CKIgamma | ADP + phosphorylated protein LRP6 | - |
? | |
ATP + protein TCF3 | Drosophila melanogaster | CKIepsilon | ADP + phosphorylated protein TCF3 | - |
? | |
ATP + protein TCF3 | Homo sapiens | CKIepsilon | ADP + phosphorylated protein TCF3 | - |
? | |
ATP + protein TCF3 | Xenopus laevis | CKIepsilon | ADP + phosphorylated protein TCF3 | - |
? | |
additional information | Drosophila melanogaster | multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase | ? | - |
? | |
additional information | Homo sapiens | multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase | ? | - |
? | |
additional information | Xenopus laevis | multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
isozymes alpha, beta, gamma1, gamm2, gamma3, delta, and epsilon | - |
Homo sapiens | - |
isozymes alpha, beta, gamma1, gamm2, gamma3, delta, and epsilon | - |
Xenopus laevis | - |
isozymes alpha, beta, gamma1, gamm2, gamma3, delta, and epsilon | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Xenopus laevis | - |
embryo | - |
Xenopus laevis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + adenomatous polyposis coli protein | i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon | Drosophila melanogaster | ADP + phosphorylated adenomatous polyposis coli protein | - |
? | |
ATP + adenomatous polyposis coli protein | i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon | Homo sapiens | ADP + phosphorylated adenomatous polyposis coli protein | - |
? | |
ATP + adenomatous polyposis coli protein | i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon | Xenopus laevis | ADP + phosphorylated adenomatous polyposis coli protein | - |
? | |
ATP + beta-catenin | phosphorylation at Ser45, priming GSK3beta phosphorylation | Drosophila melanogaster | ADP + phosphorylated beta-catenin | - |
? | |
ATP + beta-catenin | phosphorylation at Ser45, priming GSK3beta phosphorylation | Homo sapiens | ADP + phosphorylated beta-catenin | - |
? | |
ATP + beta-catenin | phosphorylation at Ser45, priming GSK3beta phosphorylation | Xenopus laevis | ADP + phosphorylated beta-catenin | - |
? | |
ATP + Gli protein | - |
Homo sapiens | ADP + phosphorylated Gli protein | - |
? | |
ATP + Gli protein | the Gli proteins are important in regulation of Hedgehog signaling, overview | Homo sapiens | ADP + phosphorylated Gli protein | - |
? | |
ATP + protein Cubitus interruptus | Ci proteins are important in regulation of Hedgehog signaling, overview | Drosophila melanogaster | ADP + phosphorylated protein Cubitus interruptus | - |
? | |
ATP + protein Cubitus interruptus | Ci proteins are important in regulation of Hedgehog signaling, overview | Xenopus laevis | ADP + phosphorylated protein Cubitus interruptus | - |
? | |
ATP + protein Cubitus interruptus | i.e. Ci, e.g. Ci-75 or Ci-155 | Drosophila melanogaster | ADP + phosphorylated protein Cubitus interruptus | - |
? | |
ATP + protein Cubitus interruptus | i.e. Ci, e.g. Ci-75 or Ci-155 | Xenopus laevis | ADP + phosphorylated protein Cubitus interruptus | - |
? | |
ATP + protein LRP6 | CKIgamma | Drosophila melanogaster | ADP + phosphorylated protein LRP6 | - |
? | |
ATP + protein LRP6 | CKIgamma | Homo sapiens | ADP + phosphorylated protein LRP6 | - |
? | |
ATP + protein LRP6 | CKIgamma | Xenopus laevis | ADP + phosphorylated protein LRP6 | - |
? | |
ATP + protein TCF3 | CKIepsilon | Drosophila melanogaster | ADP + phosphorylated protein TCF3 | - |
? | |
ATP + protein TCF3 | CKIepsilon | Homo sapiens | ADP + phosphorylated protein TCF3 | - |
? | |
ATP + protein TCF3 | CKIepsilon | Xenopus laevis | ADP + phosphorylated protein TCF3 | - |
? | |
additional information | multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase | Drosophila melanogaster | ? | - |
? | |
additional information | multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase | Homo sapiens | ? | - |
? | |
additional information | multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase | Xenopus laevis | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | outside of the kinase domain, CKI family members fall into subfamilies that have little homology to each other and differ in the length and amino acid sequence of their N- and C-terminal extensions | Drosophila melanogaster |
More | outside of the kinase domain, CKI family members fall into subfamilies that have little homology to each other and differ in the length and amino acid sequence of their N- and C-terminal extensions | Homo sapiens |
More | outside of the kinase domain, CKI family members fall into subfamilies that have little homology to each other and differ in the length and amino acid sequence of their N- and C-terminal extensions | Xenopus laevis |
Synonyms | Comment | Organism |
---|---|---|
casein kinase I | - |
Drosophila melanogaster |
casein kinase I | - |
Homo sapiens |
casein kinase I | - |
Xenopus laevis |
More | the enzyme belongs to the CKI family of serine/threonine protein kinases | Drosophila melanogaster |
More | the enzyme belongs to the CKI family of serine/threonine protein kinases | Homo sapiens |
More | the enzyme belongs to the CKI family of serine/threonine protein kinases | Xenopus laevis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Drosophila melanogaster | |
ATP | - |
Homo sapiens | |
ATP | - |
Xenopus laevis |