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Literature summary for 2.7.11.1 extracted from

  • Wei, Y.; Fu, G.; Hu, H.; Lin, G.; Yang, J.; Guo, J.; Zhu, Q.; Yu, L.
    Isolation and characterization of mouse testis specific serine/threonine kinase 5 possessing four alternatively spliced variants (2007), J. Biochem. Mol. Biol., 40, 749-756.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information splicing variant TSSKalpha is stimulated at the CREB/CRE responsive pathway Mus musculus
additional information splicing variant TSSKbeta is not stimulated at the CREB/CRE responsive pathway Mus musculus
additional information splicing variant TSSKdelta is not stimulated at the CREB/CRE responsive pathway Mus musculus
additional information splicing variant TSSKgamma is not stimulated at the CREB/CRE responsive pathway Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
gene tssk4, localization on chromosome 14qC3, DNA and amino acid sequence determination and analysis of splicing variant beta, expression of wild-type Myc-tagged TSSKbeta in HEK-293T cells Mus musculus
gene tssk4, localization on chromosome 14qC3, DNA and amino acid sequence determination and analysis of splicing variant gamma, expression of wild-type Myc-tagged TSSKdelta in HEK-293T cells Mus musculus
gene tssk4, localization on chromosome 14qC3, DNA and amino acid sequence determination and analysis of splicing variant gamma, expression of wild-type Myc-tagged TSSKgamma in HEK-293T cells Mus musculus
gene tssk4, localization on chromosome 14qC3, DNA and amino acid sequence determination and analysis of splicing variant TSSKalpha, expression of wild-type and mutant Myc-tagged TSSKalpha in HEK-293T cells Mus musculus

Protein Variants

Protein Variants Comment Organism
K54M site-directed mutagenesis of splicing variant TSSKalpha Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus phosphorylation on serine/threonine or tyrosine residues of target proteins is an essential and significant regulatory mechanism in signal transduction during many cellular and life processes, including spermatogenesis, oogenesis and fertilization, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus A3QQQ9 testis-specific serine/threonine protein kinase 5 variant alpha; alternatively spliced variant alpha of the testis-specific isozyme
-
Mus musculus A3QQR1 testis-specific serine/threonine protein kinase 5 variant gamma; alternatively spliced variant gamma of the testis-specific isozyme
-
Mus musculus A9P6P7 testis-specific serine/threonine protein kinase 5 variant beta; alternatively spliced variant beta of the testis-specific isozyme
-
Mus musculus A9P6P9 testis-specific serine/threonine protein kinase 5 variant delta; alternatively spliced variant delta of the testis-specific isozyme
-

Source Tissue

Source Tissue Comment Organism Textmining
heart high expression level of splicing variant alpha of the testis specific serine/threonine kinase Mus musculus
-
heart high expression level of splicing variant beta of the testis specific serine/threonine kinase Mus musculus
-
heart high expression level of splicing variant delta of the testis specific serine/threonine kinase Mus musculus
-
heart high expression level of splicing variant gamma of the testis specific serine/threonine kinase Mus musculus
-
spleen
-
Mus musculus
-
testis high expression level of splicing variant alpha of the testis specific serine/threonine kinase Mus musculus
-
testis high expression level of splicing variant beta of the testis specific serine/threonine kinase Mus musculus
-
testis high expression level of splicing variant delta of the testis specific serine/threonine kinase Mus musculus
-
testis high expression level of splicing variant gamma of the testis specific serine/threonine kinase Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myelin basic protein
-
Mus musculus ADP + phosphorylated myelin basic protein
-
?
ATP + Trx-His-S-CREB protein i.e. thioredoxin fusion cAMP responsive element binding protein, phosphorylation at Ser133 Mus musculus ADP + phosphorylated Trx-His-S-CREB protein
-
?
additional information phosphorylation on serine/threonine or tyrosine residues of target proteins is an essential and significant regulatory mechanism in signal transduction during many cellular and life processes, including spermatogenesis, oogenesis and fertilization, overview Mus musculus ?
-
?
additional information only splicing variant TSSK5alpha exhibits kinase activity Mus musculus ?
-
?
additional information splicing variant TSSK5beta is inactive Mus musculus ?
-
?
additional information splicing variant TSSK5delta is inactive Mus musculus ?
-
?
additional information splicing variant TSSK5gamma is inactive Mus musculus ?
-
?

Subunits

Subunits Comment Organism
More splicing variant beta has an insertion of ten amino acid residues, RLTPSLSAAG, in region VIb of the HisArgAsp domain Mus musculus
More splicing variant delta has an insertion of ten amino acid residues, RLTPSLSAAG, in region VIb of the HisArgAsp domain Mus musculus
More splicing variant gamma has an insertion of ten amino acid residues, RLTPSLSAAG, in region VIb of the HisArgAsp domain Mus musculus
More TSSK5alpha has no insertion of ten amino acid residues in region VIb of the HisArgAsp domain Mus musculus

Synonyms

Synonyms Comment Organism
testis-specific serine/threonine protein kinase 5 variant alpha
-
Mus musculus
testis-specific serine/threonine protein kinase 5 variant beta
-
Mus musculus
testis-specific serine/threonine protein kinase 5 variant delta
-
Mus musculus
testis-specific serine/threonine protein kinase 5 variant gamma
-
Mus musculus
Tssk4
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus