Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | splicing variant TSSKalpha is stimulated at the CREB/CRE responsive pathway | Mus musculus | |
additional information | splicing variant TSSKbeta is not stimulated at the CREB/CRE responsive pathway | Mus musculus | |
additional information | splicing variant TSSKdelta is not stimulated at the CREB/CRE responsive pathway | Mus musculus | |
additional information | splicing variant TSSKgamma is not stimulated at the CREB/CRE responsive pathway | Mus musculus |
Cloned (Comment) | Organism |
---|---|
gene tssk4, localization on chromosome 14qC3, DNA and amino acid sequence determination and analysis of splicing variant beta, expression of wild-type Myc-tagged TSSKbeta in HEK-293T cells | Mus musculus |
gene tssk4, localization on chromosome 14qC3, DNA and amino acid sequence determination and analysis of splicing variant gamma, expression of wild-type Myc-tagged TSSKdelta in HEK-293T cells | Mus musculus |
gene tssk4, localization on chromosome 14qC3, DNA and amino acid sequence determination and analysis of splicing variant gamma, expression of wild-type Myc-tagged TSSKgamma in HEK-293T cells | Mus musculus |
gene tssk4, localization on chromosome 14qC3, DNA and amino acid sequence determination and analysis of splicing variant TSSKalpha, expression of wild-type and mutant Myc-tagged TSSKalpha in HEK-293T cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
K54M | site-directed mutagenesis of splicing variant TSSKalpha | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | phosphorylation on serine/threonine or tyrosine residues of target proteins is an essential and significant regulatory mechanism in signal transduction during many cellular and life processes, including spermatogenesis, oogenesis and fertilization, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | A3QQQ9 | testis-specific serine/threonine protein kinase 5 variant alpha; alternatively spliced variant alpha of the testis-specific isozyme | - |
Mus musculus | A3QQR1 | testis-specific serine/threonine protein kinase 5 variant gamma; alternatively spliced variant gamma of the testis-specific isozyme | - |
Mus musculus | A9P6P7 | testis-specific serine/threonine protein kinase 5 variant beta; alternatively spliced variant beta of the testis-specific isozyme | - |
Mus musculus | A9P6P9 | testis-specific serine/threonine protein kinase 5 variant delta; alternatively spliced variant delta of the testis-specific isozyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | high expression level of splicing variant alpha of the testis specific serine/threonine kinase | Mus musculus | - |
heart | high expression level of splicing variant beta of the testis specific serine/threonine kinase | Mus musculus | - |
heart | high expression level of splicing variant delta of the testis specific serine/threonine kinase | Mus musculus | - |
heart | high expression level of splicing variant gamma of the testis specific serine/threonine kinase | Mus musculus | - |
spleen | - |
Mus musculus | - |
testis | high expression level of splicing variant alpha of the testis specific serine/threonine kinase | Mus musculus | - |
testis | high expression level of splicing variant beta of the testis specific serine/threonine kinase | Mus musculus | - |
testis | high expression level of splicing variant delta of the testis specific serine/threonine kinase | Mus musculus | - |
testis | high expression level of splicing variant gamma of the testis specific serine/threonine kinase | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myelin basic protein | - |
Mus musculus | ADP + phosphorylated myelin basic protein | - |
? | |
ATP + Trx-His-S-CREB protein | i.e. thioredoxin fusion cAMP responsive element binding protein, phosphorylation at Ser133 | Mus musculus | ADP + phosphorylated Trx-His-S-CREB protein | - |
? | |
additional information | phosphorylation on serine/threonine or tyrosine residues of target proteins is an essential and significant regulatory mechanism in signal transduction during many cellular and life processes, including spermatogenesis, oogenesis and fertilization, overview | Mus musculus | ? | - |
? | |
additional information | only splicing variant TSSK5alpha exhibits kinase activity | Mus musculus | ? | - |
? | |
additional information | splicing variant TSSK5beta is inactive | Mus musculus | ? | - |
? | |
additional information | splicing variant TSSK5delta is inactive | Mus musculus | ? | - |
? | |
additional information | splicing variant TSSK5gamma is inactive | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | splicing variant beta has an insertion of ten amino acid residues, RLTPSLSAAG, in region VIb of the HisArgAsp domain | Mus musculus |
More | splicing variant delta has an insertion of ten amino acid residues, RLTPSLSAAG, in region VIb of the HisArgAsp domain | Mus musculus |
More | splicing variant gamma has an insertion of ten amino acid residues, RLTPSLSAAG, in region VIb of the HisArgAsp domain | Mus musculus |
More | TSSK5alpha has no insertion of ten amino acid residues in region VIb of the HisArgAsp domain | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
testis-specific serine/threonine protein kinase 5 variant alpha | - |
Mus musculus |
testis-specific serine/threonine protein kinase 5 variant beta | - |
Mus musculus |
testis-specific serine/threonine protein kinase 5 variant delta | - |
Mus musculus |
testis-specific serine/threonine protein kinase 5 variant gamma | - |
Mus musculus |
Tssk4 | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |