Protein Variants | Comment | Organism |
---|---|---|
additional information | transfection of the dominant negative mutant of CK2, CK2alphaA156, to the CA1 area, but not to the DG area, decreases CK2 activity but enhances spatial memory formation, it increases SGK1 phosphorylation at Ser422, decreased Akt phosphorylation at Ser473, and increases cAMP response element-binding protein phosphorylation at Ser133, transfection significantly decreases CK2 activity in CA1 area by about 38%, compared to the control group, and downregulates CK2 signaling in CA1 neurons, while SGK1 phosphorylation at Ser422 is increased, overview | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fostriecin | protein phosphatase 2A inhibitor fostriecin reverses the memory-impairing effect of CK2alphaWT, it also reverses the effect of CK2alphaWT in decreasing SGK1 phosphorylation | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Akt | Rattus norvegicus | CK2 phosphorylates and activates Akt directly | ADP + phosphorylated Akt | - |
? | |
additional information | Rattus norvegicus | CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling by activation of Akt and inactivation of SGK1 through protein phosphatase 2A | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Sprague Dawley rats, gene CK2alpha | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Akt | CK2 phosphorylates and activates Akt directly | Rattus norvegicus | ADP + phosphorylated Akt | - |
? | |
ATP + Akt | CK2 phosphorylates and activates Akt directly, phosphorylation at Ser473 | Rattus norvegicus | ADP + phosphorylated Akt | - |
? | |
additional information | CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling by activation of Akt and inactivation of SGK1 through protein phosphatase 2A | Rattus norvegicus | ? | - |
? | |
additional information | CK2 inhibition increases SGK1 phosphorylation at Ser422 | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein kinase CK2 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |