Literature summary for 2.7.11.1 extracted from

Bolanos-Garcia, V.M.; Fernandez-Recio, J.; Allende, J.E.; Blundell, T.L.
Identifying interaction motifs in CK2beta - a ubiquitous kinase regulatory subunit (2006), Trends Biochem. Sci., 31, 654-661.

Search for more literature for 2.7.11.1

Protein Variants

Protein Variants	Comment	Organism
additional information	CK2 induces neoplastic growth when overexpressed	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	bound to the zinc finger core at residues 105-147 and coordinated by Cys109, Cys114, Cys137 ans Cys140, of the beta subunit dimer	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	CK2 phosphorylates about 300 different cellular proteins, ranging from transcription factors to proteins involved in chromatin structure and cell division, CK2 induces neoplastic growth when overexpressed	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	constitutive enzyme	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	CK2 phosphorylates about 300 different cellular proteins, ranging from transcription factors to proteins involved in chromatin structure and cell division, CK2 induces neoplastic growth when overexpressed	Homo sapiens	?	-	?
additional information	the pleiotropic protein kinase CK2 possesses many protein interaction sites	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
tetramer	heterotetramer, the dimer of dimers shows a alpha2beta2 structure, the alpha subunit CK2alpha ist a catalytic heterodimer, the beta subunit CK2beta is a regulatory compact globular homodimer, but also functions as a multisubstrate docking platform for several other binding partners, CK2beta contains a Zn2+ bound to the zinc finger core at residues 105-147, the N-terminus of CK2beta contains ligand and protein interaction sites, e.g. the juxta-dimer interface region containing residues Asp105, Arg111, Glu115, Lys134, Asp142, and Lys147, determination by the optimal docking area method, organization and interaction motifs of CK2beta, overview	Homo sapiens

Synonyms

Synonyms	Comment	Organism
CK2	-	Homo sapiens
protein kinase CK2	-	Homo sapiens

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Release 2023.1 (January 2023)