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Literature summary for 2.7.11.1 extracted from

  • Jung, H.; Seong, H.A.; Ha, H.
    Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr838 phosphorylation (2008), J. Biol. Chem., 283, 34541-34553.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.1

Application

Application Comment Organism
molecular biology results demonstrate that MPK38 physically interacts with ASK1 in vivo and acts as a positive upstream regulator of ASK1 Mus musculus

Protein Variants

Protein Variants Comment Organism
K40R kinase-dead MPK38 mutant shows no complex formation with ASK1 since MPK38-ASK1 complex formation is dependent on the activities of both kinases Mus musculus
additional information ectopic expression of wild-type MPK38, but not kinase-dead MPK38, stimulates ASK1 activity by Thr838 phosphorylation and enhances ASK1-mediated signaling to both JNK and p38 kinases Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q61846
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Source Tissue

Source Tissue Comment Organism Textmining
HaCaT cell
-
 Mus musculus
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HEK-293 cell
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 Mus musculus
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HEK-293T cell
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 Mus musculus
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SK-N-BE(2) cell
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + apoptosis signal-regulating kinase 1 MPK28 stimulates APK1 activity by Thr838 phosphorylation Mus musculus ADP + phosphorylated-apoptosis signal-regulating kinase 1
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 ?

Synonyms

Synonyms Comment Organism
MPK38
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 Mus musculus
Murine serine-threonine kinase 38
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 Mus musculus