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Literature summary for 2.7.11.1 extracted from

  • Glowczewski Bedard, L.; Dronamraju, R.; Kerschner, J.L.; Hunter, G.O.; DeVlieger Axley, E.; Boyd, A.K.; Strahl, B.D.; Mosley, A.L.
    Quantitative analysis of dynamic protein interactions during transcription reveals a role for casein kinase II in polymerase-associated factor (PAF) complex phosphorylation and regulation of histone H2B monoubiquitylation (2016), J. Biol. Chem., 291, 13410-13420 .
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
FACT may facilitate CKII recruitment to PAF-C for its subsequent phosphorylation Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + PAF-C Saccharomyces cerevisiae all five subunits of PAF-C are putative CKII targets, PAF-C and CKII are direct interacting partners, overview ADP + phospho-PAF-C
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + FACT the FACT complex can be phosphorylated in vitro in reactions containing recombinant CKII Saccharomyces cerevisiae ADP + phospho-FACT
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ATP + PAF-C all five subunits of PAF-C are putative CKII targets, PAF-C and CKII are direct interacting partners, overview Saccharomyces cerevisiae ADP + phospho-PAF-C
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 ?
ATP + PAF-C all five subunits of PAF-C are putative CKII targets, PAF-C subunits are readily phosphorylated in the presence of recombinant CKII, PAF-C and CKII are direct interacting partners, overview Saccharomyces cerevisiae ADP + phospho-PAF-C
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additional information multiple consensus motifs are phosphorylated by CKII, including [S/T]XX[E/D], SDXE, SXX[E/D], and [D/E]S[D/E]X[D/E] and many other similar motifs Saccharomyces cerevisiae ?
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Synonyms

Synonyms Comment Organism
casein kinase II
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 Saccharomyces cerevisiae
CKII
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 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function CKII is a constitutively active serine/threonine kinase that is implicated in the phosphorylation of a number of transcription-related proteins including RNAPII itself. Role for casein kinase II in polymerase-associated factor (PAF) complex phosphorylation and regulation of histone H2B monoubiquitylation. CKII is an important regulator of histone H2B-K123ub1, likely through its regulation of PAF-C and FACT, dynamic relationship between FACT, CKII, and PAF-C. PAF-C and CKII are direct interacting partners, while FACT may facilitate CKII recruitment to PAF-C for its subsequent phosphorylation Saccharomyces cerevisiae