Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon cancer cell | - |
Homo sapiens | - |
SW-480 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
RAF proto-oncogene serine/threonine-protein kinase | - |
Homo sapiens |
RAF1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | overexpression of microRNA miR-455 decreases protein expression of RAF proto-oncogene serine/threonine-protein kinase (RAF1) but has no effect on mRNA level. miR-455 regulates RAF1 expression directly. Overexpression of miR-455 significantly inhibits the proliferation and the invasion of SW480, but has no effect on apoptosis. Overexpression of RAF1 partially reverses the inhibitory effect of miR-455 on the growth and the invasion of SW480 | down |
General Information | Comment | Organism |
---|---|---|
additional information | overexpression of microRNA miR-455 decreases protein expression of RAF proto-oncogene serine/threonine-protein kinase (RAF1) but has no effect on mRNA level. miR-455 regulates RAF1 expression directly. Overexpression of miR-455 significantly inhibits the proliferation and the invasion of SW480, but has no effect on apoptosis. Overexpression of RAF1 partially reverses the inhibitory effect of miR-455 on the growth and the invasion of SW-480. MicroRNAs (miRNAs) are a class of small (18-25 nucleotides long) noncoding RNAs with important posttranscriptional regulatory functions. miRNAs play important roles in various physiological and pathological processes including carcinogenesis in various solid cancers including colorectal cancer | Homo sapiens |