Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-Dopa | activates GSK-3beta at high dose | Homo sapiens | |
additional information | activation of GSK-3beta is absolutely dependent on the presence of alpha-synuclein | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-catenin | - |
Homo sapiens | ADP + phosphorylated beta-catenin | - |
? | |
ATP + cAMP response element-binding protein | - |
Homo sapiens | ADP + phosphorylated cAMP response element-binding protein | - |
? | |
ATP + heat shock factor-1 | - |
Homo sapiens | ADP + phosphorylated heat shock factor-1 | - |
? | |
ATP + Jun | - |
Homo sapiens | ADP + phosphorylated Jun | - |
? | |
ATP + Myc | - |
Homo sapiens | ADP + phosphorylated Myc | - |
? | |
ATP + protein tau | - |
Homo sapiens | ADP + protein tau phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3 | - |
Homo sapiens |
GSK-3alpha | isoform | Homo sapiens |
GSK-3beta | isoform | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | increased GSK-3 correlates with increased cell death, GSK-3 plays a very important role in L-DOPA neurotoxicity, as well as in neurodegeneration | Homo sapiens |