Activating Compound | Comment | Organism | Structure |
---|---|---|---|
auto-inducible protein I | dose-dependent activation by autoinducing peptide | Staphylococcus aureus |
Protein Variants | Comment | Organism |
---|---|---|
G394A/G396A | completely inactive | Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein L-histidine | Staphylococcus aureus | - |
ADP + protein N-phospho-L-histidine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | AgrC forms ligand-independent dimers that undergo trans-autophosphorylation upon interaction with autoinducing peptide | Staphylococcus aureus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein L-histidine | - |
Staphylococcus aureus | ADP + protein N-phospho-L-histidine | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | AgrC forms ligand-independent dimers that undergo trans-autophosphorylation upon interaction with autoinducing peptide | Staphylococcus aureus |
Synonyms | Comment | Organism |
---|---|---|
AgrC | - |
Staphylococcus aureus |
receptor histidine kinase | - |
Staphylococcus aureus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Staphylococcus aureus |
General Information | Comment | Organism |
---|---|---|
physiological function | the AgrC receptor histidine kinase detects its autoinducing peptide ligand and generates an intracellular signal resulting in secretion of virulence factors | Staphylococcus aureus |