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Literature summary for 2.7.2.3 extracted from

  • Lee, C.S.; O'Sullivan, W.J.
    Properties and mechanism of human erythrocyte phosphoglycerate kinase (1975), J. Biol. Chem., 250, 1275-1281.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoic acid) complete loss of activity Homo sapiens
Ca2+ inhibition above 1 mM Homo sapiens
Co2+ inhibits at high concentrations Homo sapiens
MgADP-
-
Homo sapiens
MgGDP-
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ can partially replace Mg2+ in activation Homo sapiens
Co2+ can partially replace Mg2+ in activation Homo sapiens
divalent cation
-
Homo sapiens
Mn2+ can partially replace Mg2+ in activation Homo sapiens
additional information no activation by: Sr2+ Homo sapiens
Zn2+ no activation Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
44500
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
600 700 purified enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 3-phospho-D-glycerate absolute specificity for 3-phospho-D-glycerate Homo sapiens ADP + 1,3-diphosphoglycerate
-
r
CTP + 3-phospho-D-glycerate no activity Homo sapiens CDP + 1,3-diphosphoglycerate
-
?
dATP + 3-phospho-D-glycerate 27% of the activity with ATP Homo sapiens dADP + 1,3-diphosphoglycerate
-
?
GTP + 3-phospho-D-glycerate 36% of the activity with ATP Homo sapiens GDP + 1,3-diphosphoglycerate
-
?
ITP + 3-phospho-D-glycerate 45% of the activity with ATP Homo sapiens IDP + 1,3-diphosphoglycerate
-
?
additional information also catalyzes ADP-ATP exchange reaction Homo sapiens ?
-
?
UTP + 3-phospho-D-glycerate no activity Homo sapiens UDP + 1,3-diphosphoglycerate
-
?

Cofactor

Cofactor Comment Organism Structure
ADP
-
Homo sapiens
ATP true substrate is the magnesium complexes of ATP Homo sapiens
ATP required as phosphate donor Homo sapiens
GTP
-
Homo sapiens
ITP
-
Homo sapiens