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Literature summary for 2.7.2.3 extracted from

  • Zieker, D.; Koenigsrainer, I.; Tritschler, I.; Loeffler, M.; Beckert, S.; Traub, F.; Nieselt, K.; Buehler, S.; Weller, M.; Gaedcke, J.; Taichman, R.S.; Northoff, H.; Bruecher, B.L.; Koenigsrainer, A.
    Phosphoglycerate kinase 1 a promoting enzyme for peritoneal dissemination in gastric cancer (2010), Int. J. Cancer, 126, 1513-1520.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine PGK1 may serve as prognostic marker and/or be a potential therapeutic target to prevent dissemination of gastric carcinoma cells into the peritoneum Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
into plasmid vector pEF-IRES, overexpressed in MKN-45 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus patients with peritoneal carcinomatosis show a medium to strong nuclear staining for PGK1 Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gastric adenocarcinoma cell line
-
 Homo sapiens
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MKN-45 cell distinct expression of PGK1 Homo sapiens
-

Synonyms

Synonyms Comment Organism
PGK1
-
 Homo sapiens
phosphoglycerate kinase 1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens considerable downregulation of PGK1 expression in siPGK1-treated cells compared to control cells down
Homo sapiens CXCR4 regulates the expression of PGK1. Overexpression of PGK1 in patients with development of peritoneal carcinomatosis up

General Information

General Information Comment Organism
physiological function PGK1 regulates the expression of CXCR4 and beta-catenin at the mRNA and protein levels. PGK1 and CXCR4 regulate their expression reciprocally. Overexpression of PGK1 dramatically increases the invasiveness of gastric cancer cells. Inhibition of CXCR4 in cells overexpressing PGK1 produces only a moderate reduction of invasiveness suggesting that, PGK1 itself has a critical role in tumor invasiveness. PGK1 may be a crucial enzyme in peritoneal dissemination, enhanced expression of PGK1 and its signaling targets CXCR4 and beta-catenin in gastric cancer cells promote peritoneal carcinomatosis Homo sapiens