Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.2.4 extracted from

  • Dawson Funkhouser, J.; Abraham, A.; Smith, V.A.; Smith W.G.
    Kinetic and molecular properties of lysine-sensitive aspartokinase. Factors influencing the lysine-mediated association reaction and their relationship to the cooperativity of lysine inhibition (1974), J. Biol. Chem., 249, 5478-5484.
    View publication on PubMed
Search for more literature for 2.7.2.4

Inhibitors

Inhibitors Comment Organism Structure
L-lysine
-
 Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
166000
-
 in presence of KCl and L-lysine at 11°C, sedimentation equilibrium Escherichia coli
181000
-
 in presence of KCl and L-lysine at 25°C, sedimentation equilibrium Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-aspartate Escherichia coli first step in the branched biosynthetic pathway for the synthesis of L-lysine, L-methionine, L-threonine, L-isoleucine and diaminopimelic acid ADP + 4-phospho-L-aspartate
-
 r
ATP + L-aspartate Escherichia coli B / ATCC 11303 first step in the branched biosynthetic pathway for the synthesis of L-lysine, L-methionine, L-threonine, L-isoleucine and diaminopimelic acid ADP + 4-phospho-L-aspartate
-
 r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli B / ATCC 11303
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-aspartate
-
 Escherichia coli ADP + 4-phospho-L-aspartate
-
 r
ATP + L-aspartate first step in the branched biosynthetic pathway for the synthesis of L-lysine, L-methionine, L-threonine, L-isoleucine and diaminopimelic acid Escherichia coli ADP + 4-phospho-L-aspartate
-
 r
ATP + L-aspartate
-
 Escherichia coli B / ATCC 11303 ADP + 4-phospho-L-aspartate
-
 r
ATP + L-aspartate first step in the branched biosynthetic pathway for the synthesis of L-lysine, L-methionine, L-threonine, L-isoleucine and diaminopimelic acid Escherichia coli B / ATCC 11303 ADP + 4-phospho-L-aspartate
-
 r

Subunits

Subunits Comment Organism
tetramer 4 * 46000-50000, SDS-PAGE Escherichia coli