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Literature summary for 2.7.2.4 extracted from
- Effect of different levels of aspartokinase on the lysine production by Corynebacterium lactofermentum (1995), Appl. Microbiol. Biotechnol., 43, 76-82.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Corynebacterium flavescens |
| ask-asd operon cloned | Corynebacterium glutamicum |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| G345D | mutation in the beta-subunit of the ask gene | Corynebacterium flavescens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | completely resistant to inhibition by mixtures of L-lysine and threonine | Corynebacterium glutamicum |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 18000 | - |
1 * 18000 + 1 * 45000, Western blot immunoanalysis | Corynebacterium flavescens |
| 45000 | - |
1 * 18000 + 1 * 45000, Western blot immunoanalysis | Corynebacterium flavescens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-aspartate | Corynebacterium glutamicum | - |
ADP + 4-phospho-L-aspartate | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Corynebacterium flavescens | - |
N13 | - |
| Corynebacterium flavescens N13 | - |
N13 | - |
| Corynebacterium glutamicum | Q46133 | ATCC 21799, nucleotide sequence encoding the beta-subunit | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.034 | - |
- |
Corynebacterium glutamicum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-aspartate | - |
Corynebacterium glutamicum | ADP + 4-phospho-L-aspartate | - |
r | |
| additional information | no isoenzymes | Corynebacterium glutamicum | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | 1 * 18000 + 1 * 45000, Western blot immunoanalysis | Corynebacterium flavescens |
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