Application | Comment | Organism |
---|---|---|
medicine | arginine kinase is a possible chemotherapy target for Chagas disease | Trypanosoma cruzi |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
agmatine | 5fold higher concentration than L-Arg, 20% inhibition | Trypanosoma cruzi | |
canavanine | 5fold higher concentration than L-Arg, 50% inhibition | Trypanosoma cruzi | |
Ethylguanidine | 5fold higher concentration than L-Arg, 22% inhibition | Trypanosoma cruzi | |
His | 5fold higher concentration than L-Arg, 50% inhibition | Trypanosoma cruzi | |
L-Asp | 5fold higher concentration than L-Arg, 25% inhibition | Trypanosoma cruzi | |
L-canavanine | - |
Trypanosoma cruzi | |
L-Glu | 5fold higher concentration than L-Arg, 31% inhibition | Trypanosoma cruzi | |
L-homoarginine | 5fold higher concentration than L-Arg, 33% inhibition | Trypanosoma cruzi | |
L-Lys | 5fold higher concentration than L-Arg, 25% inhibition | Trypanosoma cruzi | |
L-nitroarginine | 5fold higher concentration than L-Arg, 28% inhibition | Trypanosoma cruzi | |
N-methyl-L-Arg | 5fold higher concentration than L-Arg, 28% inhibition | Trypanosoma cruzi |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.3 | - |
ATP | 30°C, pH 7.3 | Trypanosoma cruzi | |
0.3 | - |
L-Arg | 30°C, pH 7.3 | Trypanosoma cruzi |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | a divalent cation such as Mg2+, Mn2+ or Ca2+ is required | Trypanosoma cruzi | |
Mg2+ | a divalent cation such as Mg2+, Mn2+ or Ca2+ is required | Trypanosoma cruzi | |
Mn2+ | a divalent cation such as Mg2+, Mn2+ or Ca2+ is required | Trypanosoma cruzi |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40201 | - |
x * 40201, calculation from nucleotide sequence | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | O96507 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-Arg | - |
Trypanosoma cruzi | ADP + Nomega-phospho-L-Arg | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 40201, calculation from nucleotide sequence | Trypanosoma cruzi |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.2 | - |
- |
Trypanosoma cruzi |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
6 | - |
L-canavanine | pH 7.3, 30°C | Trypanosoma cruzi | |
7 | - |
L-homoarginine | pH 7.3, 30°C | Trypanosoma cruzi |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Trypanosoma cruzi | theoretical value calculated from amino acid sequence | - |
7 |