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Literature summary for 2.7.3.3 extracted from

  • Adeyemi, O.S.; Arowolo, A.T.; Hetta, H.F.; Al-Rejaie, S.; Rotimi, D.; Batiha, G.E.
    Apoferritin and apoferritin-capped metal nanoparticles inhibit arginine kinase of Trypanosoma brucei (2020), Molecules, 25, 3432 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.3.3

Inhibitors

Inhibitors Comment Organism Structure
apoferritin mixed inhibition Trypanosoma brucei
apoferritin-Ag nanoparticle interaction with arginine kinase leads to more than 70% reduction in the enzyme activity, mixed inhibition Trypanosoma brucei
apoferritin-Au nanoparticle interaction with arginine kinase leads to more than 70% reduction in the enzyme activity, mixed inhibition Trypanosoma brucei
apoferritin-Pt nanoparticle interaction with arginine kinase leads to more than 70% reduction in the enzyme activity, mixed inhibition Trypanosoma brucei

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
 ATP pH 8.6, 30°C Trypanosoma brucei
0.021
-
 L-arginine pH 8.6, 30°C Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-arginine Trypanosoma brucei
-
 ADP + Nomega-phospho-L-arginine
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-arginine
-
 Trypanosoma brucei ADP + Nomega-phospho-L-arginine
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000001
-
 apoferritin pH 8.6, 30°C, ATP as a variable substrate while L-arginine is fixed at 2 mM Trypanosoma brucei
0.000002
-
 apoferritin-Pt nanoparticle pH 8.6, 30°C, ATP as a variable substrate while L-arginine is fixed at 2 mM Trypanosoma brucei
0.000003
-
 apoferritin-Au nanoparticle pH 8.6, 30°C, ATP as a variable substrate while L-arginine is fixed at 2 mM Trypanosoma brucei
0.000057
-
 apoferritin-Ag nanoparticle pH 8.6, 30°C, ATP as a variable substrate while L-arginine is fixed at 2 mM Trypanosoma brucei
0.000062
-
 apoferritin pH 8.6, 30°C, L-arginine as a variable when ATP is fixed at 0.5 mM Trypanosoma brucei
0.00016
-
 apoferritin-Au nanoparticle pH 8.6, 30°C, L-arginine as a variable when ATP is fixed at 0.5 mM Trypanosoma brucei
0.000168
-
 apoferritin-Ag nanoparticle pH 8.6, 30°C, L-arginine as a variable when ATP is fixed at 0.5 mM Trypanosoma brucei
0.000245
-
 apoferritin-Pt nanoparticle pH 8.6, 30°C, L-arginine as a variable when ATP is fixed at 0.5 mM Trypanosoma brucei