Protein Variants | Comment | Organism |
---|---|---|
additional information | expression of RNA interference directed against AK4 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + AMP | Homo sapiens | - |
GDP + ADP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27144 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + AMP | - |
Homo sapiens | GDP + ADP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
adenylate kinase 4 | - |
Homo sapiens |
AK3 | - |
Homo sapiens |
AK4 | - |
Homo sapiens |
GTP: AMP phosphotra nsferase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | HepG2 cells show high AK4 levels, which decrease under hypoxia | down |
Homo sapiens | in HEK293 cells, hypoxia increases AK4 expression | up |
General Information | Comment | Organism |
---|---|---|
malfunction | in HEK-293 cells, RNA inter ference (RNAi) directed against AK4 inhibits proliferation and promotes death. RNAi directed against AK4 inhibits cell proliferation and causes death in both cell types, HEK-293 and Hep-G2, although cell cycle parameters are affected only in Hep-G2 cells. Reductions of AK4 levels are always associated with cell death | Homo sapiens |
physiological function | adenylate kinase isozyme 4 belongs to a family of nucleotide monophosphate kinases involved in energy metabolism. Enzyme AK4 play a role in protection from stress. In HEK-293 cells, hypoxia increases AK4 expression but does not affect proliferation or viability. Hep-G2 cells show much higher AK4 levels, which decrease under hypoxia along with markedly reduced cell proliferation and increased cell death. AK4-mediated stress protection is not limited to one particular death scenario | Homo sapiens |