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Literature summary for 2.7.4.10 extracted from

  • Kong, F.; Binas, B.; Moon, J.H.; Kang, S.S.; Kim, H.J.
    Differential expression of adenylate kinase 4 in the context of disparate stress response strategies of HEK293 and HepG2 cells (2013), Arch. Biochem. Biophys., 533, 11-17.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information expression of RNA interference directed against AK4 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + AMP Homo sapiens
-
GDP + ADP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P27144
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + AMP
-
Homo sapiens GDP + ADP
-
?

Synonyms

Synonyms Comment Organism
adenylate kinase 4
-
Homo sapiens
AK3
-
Homo sapiens
AK4
-
Homo sapiens
GTP: AMP phosphotra nsferase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens HepG2 cells show high AK4 levels, which decrease under hypoxia down
Homo sapiens in HEK293 cells, hypoxia increases AK4 expression up

General Information

General Information Comment Organism
malfunction in HEK-293 cells, RNA inter ference (RNAi) directed against AK4 inhibits proliferation and promotes death. RNAi directed against AK4 inhibits cell proliferation and causes death in both cell types, HEK-293 and Hep-G2, although cell cycle parameters are affected only in Hep-G2 cells. Reductions of AK4 levels are always associated with cell death Homo sapiens
physiological function adenylate kinase isozyme 4 belongs to a family of nucleotide monophosphate kinases involved in energy metabolism. Enzyme AK4 play a role in protection from stress. In HEK-293 cells, hypoxia increases AK4 expression but does not affect proliferation or viability. Hep-G2 cells show much higher AK4 levels, which decrease under hypoxia along with markedly reduced cell proliferation and increased cell death. AK4-mediated stress protection is not limited to one particular death scenario Homo sapiens